Effect of Different Kind of Plant Oil Sources on Serum and Hepatic Lipid levels of Streptozotocin-induced Diabetic Mice

Streptozotocin으로 유발한 당뇨 마우스에서 식물성 지방 급원에 따른 혈액 및 간조직의 지질 조성

  • Lee, Sung-Hyeon (Agriproduct Science Division, National Rural Living Science Institute, NIAST, RDA) ;
  • Chun, Hye-Kyung (Agriproduct Science Division, National Rural Living Science Institute, NIAST, RDA) ;
  • Park, Hong-Ju (Agriproduct Science Division, National Rural Living Science Institute, NIAST, RDA) ;
  • Lee, Yeon-Sook (Dept. of Food and Nutrition, Seoul National University) ;
  • Chang, Soon-Ok (Dept. of Food and Nutrition, The University of Suwon)
  • 이성현 (농촌진흥청 농업과학기술원 농촌생활연구소 농산물가공이용과) ;
  • 전혜경 (농촌진흥청 농업과학기술원 농촌생활연구소 농산물가공이용과) ;
  • 박홍주 (농촌진흥청 농업과학기술원 농촌생활연구소 농산물가공이용과) ;
  • 이연숙 (서울대학교 식품영양학과) ;
  • 장순옥 (수원대학교 식품영양학과)
  • Published : 2003.07.01


This study was carried out to compare the effects of different plant oil sources on lipid metabolism of insulin dependent diabetic mice. Streptozotocin-induced (65 mg/kg B.W.) diabetic mice were fed four kinds of experimental diets with 20% lipid, which composed of 10% lard, and 10% soy bean oil (SBO), 10% rice germ oil (RGO), 10% rice brab oil (RBO) and 10% sesame oil (SSO) respectively, for 7 weeks. Diet intake, body weight, organs weights and lipids levels of serum, liver and feces were measured. There was no significant difference in diet intake and body weight among experimental groups. But the concentrations of serum triglyceride of RGO and RBO groups, and of serum total cholesterol of RGO and SSO groups were lower than those of the others. The hepatic total cholesterol level was the lowest in RGO group. The contents of total lipid and total cholesterol excreted in feces of RGO and RBO groups were higher than those of SBO and SSO groups. These results suggested that rice germ oil can effectively reduce serum triglyceride level and hepatic total cholesterol concentration of insulin dependent diabetic mice than rice bran oil, soy bean oil and sesame oil, and hypolipidemic effect of rice germ oil be due to increasing fecal lipid excretion. But we need to investigate the more detailed factors on lipid reducing effect in rice germ oil and rice bran oil.


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