Pathogenesis of Hong Kong H5N1 Influenza Virus in Immunodeficient Mice

Hong Kong H5N1 인플루엔자 바이러스의 면역부전 마우스에 대한 병리발생

  • Park, Chun-ho (Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University)
  • 박천호 (북해도대학교 수의과대학)
  • Accepted : 2003.06.04
  • Published : 2003.06.30


Virulent and avirulent H5N1 viruses were inoculated intranasally to BALB/c and immunodeficient mice, and compared the pathogenesis by histology and immunohistochemistry. All of mice infected with virulent virus died by systemic infection at 6 to 7 days postinfection (PI). BALB/c mice infected with avirulent virus survived from the infection, whereas immunodeficient mice showed nervous symptoms in addition to respiratory disease and died at 13 days PI. Viral positive antigens was detected from multiple organs including central nervous system in immunodeficient mice infected with avirulent virus. These results suggest that avirulent H5N1 influenza virus can aquire the multiple tissue tropism under immunosuppresed condition and host immune system is a important factor to protect the development of disease.


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