The Distribution of TrkA in the Olfactory Bulb and Basal Nucleus of the Mongolian Gerbil after Birth

출생 후 몽골리안 저빌의 후각망울과 기저핵에서 TrkA의 분포

  • Hou, Xilin (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Il-kwon (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Kyung-youl (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Mi-sun (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Sang-keun (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Kang-yi (College of Oriental Medicine, Daejeon University) ;
  • Lee, Geun-jwa (Chungnam Livestock & Veterinary Service Institute) ;
  • Kim, Moo-kang (College of Veterinary Medicine, Chungnam National University)
  • 후시린 (충남대학교 수의과대학) ;
  • 박일권 (충남대학교 수의과대학) ;
  • 이경열 (충남대학교 수의과대학) ;
  • 박미선 (충남대학교 수의과대학) ;
  • 김상근 (충남대학교 수의과대학) ;
  • 이강이 (대전대학교 한의과대학) ;
  • 이근좌 (충남축산위생연구소) ;
  • 김무강 (충남대학교 수의과대학)
  • Accepted : 2003.06.25
  • Published : 2003.09.25

Abstract

TrkA is an essential component of the high affinity NGF receptor necessary to the mediate biological effects of the neurotrophins NGF. Here we report on the expression of TrkA in the olfactory bulb and basal nucleus of Mongolian gerbil brain during the postnatal development. The expressions of TrkA were identified in a immunohistochemical method. Higher levels of TrkA immunoreactivity were detected in septum than that in olfactory bulb and caudate putamen (CPu). But TrkA was not observed before postnatal days (PND6) in olfactory bulb and PND9 in CPu. No TrkA-positive cell was detectable in the olfactory fiber layer. Several regions, such as olfactory bulb and CPu, showed weak labeling. These data show that expression of TrkA is developmentally regulated during postnatal Mongolian gerbil brain development and suggest that high affinity neurotrophinreceptors mediate a transient response to neurotrophins in many regions during the brain ontogeny.

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