Evaluation of Micronucleus Frequency in Cytokinesis-blocked Bovine Lymphocytes from Regions around Wolsong Nuclear Power Plant

세포질 분열 차단 림프구를 이용한 월성원자력발전소 주변 소의 미소핵 발생 평가

  • Kim, Se-ra (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Tae-hwan (Korea Institute of Radiological & Medical Science) ;
  • Kim, Sung-ho (College of Veterinary Medicine, Chonnam National University)
  • Accepted : 2003.07.23
  • Published : 2003.09.25


Cytogenetic and hematological analysis was performed in bovine peripheral blood from the regions around Wolsong nuclear power plant and control area. The frequency of micronuclei (MN) in peripheral blood lymphocytes from cattle was used as a biomarker of radiobiological effects resulting from exposure to environmental radiation. An estimated dare of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the bovine lymphocytes exposed in vitro to radiation over the range from 0 Gy to 4 Gy. MN rates in lymphocytes of cattle from Wolsong nuclear power plant and control area were 9.87/1,000 and 9.60/1,000, respectively. There were no significant differences in MN frequencies and hematological values in cattle between Wolsong and control area. The study indicates that the MN assay is a rapid, sensitive and accurate method that can be used to monitor a large population exposed to radiation.


Supported by : 과학기술부


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