The Effect of Acupuncture on the Intestinal Smooth Muscle Dysfunction Caused by Enteric Bacterial Infection in Weaning Piglet

돼지의 세균성 위장관 질환에 따른 평활근 기능 이상에 대한 침술의 효과

  • Kim, Tae-wan (College of Veterinary Medicine, Seoul National University) ;
  • La, Jun-ho (College of Veterinary Medicine, Seoul National University) ;
  • Sung, Tae-sik (College of Veterinary Medicine, Seoul National University) ;
  • Kang, Jeong-woo (College of Veterinary Medicine, Seoul National University) ;
  • Nam, Tchi-chou (College of Veterinary Medicine, Seoul National University) ;
  • Choi, Min-cheol (College of Veterinary Medicine, Seoul National University) ;
  • Yoon, Yeo-sung (College of Veterinary Medicine, Seoul National University) ;
  • Yang, Il-suk (College of Veterinary Medicine, Seoul National University)
  • Accepted : 2003.08.07
  • Published : 2003.09.25

Abstract

It is now generally accepted that acupuncture is effective in diarrhea caused by bacterial infection. However, its effect on the intestinal smooth muscle dysfunction is not clear. Therefore, we investigated the effect of acupuncture therapy at Jiao-chao (GV-1) on the intestinal muscle dysfunction in weaning piglets orally infected by Escherichia coli. The animals are divided into four groups; 1) E. coli + no-treatment, 2) E. coli + antibiotic, 3) E. coli + acupuncture, 4) normal group. In the three E. coli infected groups, low frequency electrical field stimulation (EFS, 1 Hz) provoked triphasic responses composed of initial relaxation followed by on-contraction and off-contraction. While in the normal group, EFS (1Hz) induced biphasic responses composed of relaxation during the stimulation and off-contraction. At the high frequency (16Hz) EFS, both on-contraction and off-contraction of the E. coli + antibiotic, E. coli + acupuncture and the normal group were larger than those of the E. coli + no-treatment group. In the non-adrenergic non-cholinergic (NANC) condition, only biphasic responses occurred to EFS in all experimental groups and the off-contraction of E. coli + antibiotic, E. coli + acupuncture and the normal group were larger than those of the E. coli + no-treatment group. The response to carbachol of those three groups was also significantly greater than that of the E. coli + no-treatment group. These results suggest that acupuncture is as effective as antibiotic in the dysfunction of colonic circular muscle caused by E. coli infection. The maintenance of contractile neuromuscular transmission seems to be involved in the mechanism of the acupuncture effects on diarrhea.

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