Porcine Circovirus Infection in Weaned Pigs with Postweaning Multisystemic Wasting Syndrome in Korea

국내 이유자돈의 써코바이러스 감염에 의한 이유후전신소모성 증후군

  • Kim, Jae-hoon (Department of Veterinary Medicine, Cheju National University) ;
  • Roh, In-soon (Pathology Division, National Veterinary Research and Quarantine Service) ;
  • Sohn, Hyun-joo (Pathology Division, National Veterinary Research and Quarantine Service) ;
  • Jean, Young-hwa (Pathology Division, National Veterinary Research and Quarantine Service) ;
  • Hwang, Eui-kyung (College of Life Science & Natural Resources, Sangji University) ;
  • Yoon, Kyoung-jin (Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University)
  • 김재훈 (제주대학교 수의학과) ;
  • 노인순 (국립수의과학검역원 병리과) ;
  • 손현주 (국립수의과학검역원 병리과) ;
  • 진영화 (국립수의과학검역원 병리과) ;
  • 황의경 (상지대학교 생명자원과학대학 동물자원학과) ;
  • 윤경진 (아이오와 주립대학)
  • Accepted : 2003.08.25
  • Published : 2003.09.25

Abstract

Eight nursery to grower pigs exhibiting weight loss and sudden death were diagnosed as postweaning multisystemic wasting syndrome (PMWS) based on the results of gross findings, histopathology, immunohistochemistry, fluorescent antibody test, virus isolation, PCR, serology, and electron microscopy. Groosly, the pigs had a rough hair coats and were severely emaciated. And moot lymph nodes were pale and enlarged. Lungs were not fully collapsed and exhibited 10 to 40% pale red cranioventral consolidation. Histopathologically, typical lymphohistiocytic interstitial to bronchointerstitial pneumonia, chronic lymphadenitis, severe lymphoid depletion, and basophilic intracytoplasmic inclusions were noted in the most lymphoid tissues. Porcine circovirus panicles were observed in the inguinal lymph node of the pigs by electron microscopy. Porcine circovirus type 2 (PCV2) antigens or viral DNAs were detected in the lesions of all pigs using immunohistochemistry or PCR. Two PCV2 were isolated from a homogenate of pooled lung and lymph node in 2 of the 5 pigs. Additionally, antigens of porcine reproductive and respiratory syndrome virus (PRRSV) and Hemophilus (H.) parasuis were also detected by immunofluorescent antibody test. Serologically, 55% of randomly selected sows and fattening pigs was serum antibody positive to PCV2 by an indirect fluorescent antibody (IFA) test and approximately 18 % of animals in the herd were serologically pooitive by the ELISA kit for PRRSV. To our knowledge, this is the first report of PMWS co-infected with PCV-2, PRRS, and H. parasuis in Korea.

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