Anaphylactoid Reaction Induced by Administration Dirofilaria immitis Extracts

개 심장사상충 추출액 투여에 의한 Anaphylactoid Reaction

  • Lee, Jee-young (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-ho (College of Veterinary Medicine, Chungnam National University) ;
  • Kwon, Hyun-ju (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myung-cheol (College of Veterinary Medicine, Chungnam National University) ;
  • Yun, Hyo-in (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Duek-hwan (College of Veterinary Medicine, Chungnam National University)
  • 이지영 (충남대학교 수의과대학) ;
  • 송근호 (충남대학교 수의과대학) ;
  • 권현주 (충남대학교 수의과대학) ;
  • 김명철 (충남대학교 수의과대학) ;
  • 윤효인 (충남대학교 수의과대학) ;
  • 김덕환 (충남대학교 수의과대학)
  • Accepted : 2003.08.06
  • Published : 2003.09.25

Abstract

This study was performed to clarify the induction possibility of anaphylactoid reactions by the administration with the heartworm extracts, and, if any, to elucidate different virulences in terms of the protein concentrdtions and sexes of Dirofilaria immitis. Twenty three clinically healthy D. immitis-free adult dogs were used in the present study. The experimental animals were divided into 5 groups. Group A (5 heads) was administered with an female heartworm extract containing 0.1 g/dl protein concentration. Group B (4 heads) was administered with an male heartworm extract containing 0.1g/dl protein concentration. Group C (5 heads) was administered with an female heartworm extract containing 0.2 g/dl protein concentration. Group D (4 heads) was administered with an male heartworm extract containing 0.2 g/dl protein concentration. Group E (5 heads) was administered with an female heartworm extract containing 0.4 g/dl protein concentration. The changes of clinical symptoms and vital signs (body temperature, heart rate and respiration rate) were examined before and 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours and 24 hours after injection with the extracts, respectively. In addition, the changes of hematological values (RBC, PCV and total leukocytes counts), serum chemical values (ALP and CK) were determined. It was considered that heartworm extract could induce anaphylactoid reaction and adult female heartworm extract was more affective than those of adult male heartworm extract in the changes of clinical symptoms, vital signs, hematological values and serum chemical values.

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