Natural Antibiotics: Antimicrobial Peptides

천혜의 항생제: 항균펩티드

  • 김연숙 (강릉대학교 치과대학 구강병리학 교실) ;
  • 김정재 (강릉대학교 치과대학 구강미생물학 및 면역학 교실) ;
  • 최영님 (강릉대학교 치과대학 구강미생물학 및 면역학 교실)
  • Published : 2003.02.01


Antimicrobial Peptides are natural antibiotics evolved by many plants, invertebrate, and vertebrate to defend against the microbial infection. Antimicrobial peptides show a broad-spectrum antimicrobial activity with little opportunity for the development of resistance since they target microbial membranes that distinguish microbes from enkaryotic cells. The oral cavity is constantly exposed to microbial challenges and antimicrobial peptides play an important role in managing the oral health. With the increase of resistant micro-organisms to conventional antibiotics, antimicrobial peptides are attracting interests as novel antibiotics. In this review, the characteristics of antimicrobial of antimicrobial peptides including the classification, mechanism of action, resistance, and expression in the oral cavity have been discussed in the prospects of application to oral disease.