DOI QR코드

DOI QR Code

Analysis of 2-Mercapro-1-Methylimidazole in Controlling Drug of Thyroid by Differential Pulse Polarography

펄스차이 폴라로그래피를 이용한 갑상선기능조절 약제 중의 2-mercapto-1-methyl-imidazole 분석

  • Published : 2004.04.20

Abstract

The determination of 2-mercapto-1-methyl-imidazole (MMI) in 5.0${\times}10^{-2}$ M lithium perchlorate suporting electrolyte has been investigated by the differential pulse polarography. The optimum condition of MMI analysis was as follows; -0.9 volts initial potential, 0.08 mV pulse height, 2 mV/sec scan rate, and medium mercury drop size. Standard calibration curve showed a good linearlity in the range of 1.0${\times}10^{-7}M\;to\;8.0{\times}10^{-5}$ M and the detection limit has been (2.2${\pm}0.1){\times}0.1^{-9}$ M. This method was applicated for the determination of MMI in antithyroid drug without interference of additives.

Keywords

Antithyroid;2-Mercapto-1-Methyl-imidazole;Differential Pulse Polarography

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