Effect of Saururus chinensis (Lour.) Baill. Aquacupuncture on Anaphlylaxis in Mice

삼백초약침액(三白草藥鍼液)이 아나필락시스에 미치는 영향

  • Choi, Kyu-Jung (Dept. of Meridian & Acupoint.Research Institute, College of Oriental Medicine, Dongeui University) ;
  • Lee, So-Young (Dept. of Physiology.Biomedical Research Center, College of Oriental Medicine, Dongeui University) ;
  • Kang, Kyung-Hwa (Dept. of Physiology.Biomedical Research Center, College of Oriental Medicine, Dongeui University) ;
  • Lee, Yong-Tae (Dept. of Physiology.Biomedical Research Center, College of Oriental Medicine, Dongeui University) ;
  • Song, Choon-Ho (Dept. of Meridian & Acupoint.Research Institute, College of Oriental Medicine, Dongeui University)
  • 최규정 (동의대학교 한의과대학 경혈학교실.한의학연구소) ;
  • 이소영 (동의대학교 한의과대학 생리학교실.한방바이오연구센터) ;
  • 강경화 (동의대학교 한의과대학 생리학교실.한방바이오연구센터) ;
  • 이용태 (동의대학교 한의과대학 생리학교실.한방바이오연구센터) ;
  • 송춘호 (동의대학교 한의과대학 경혈학교실.한의학연구소)
  • Published : 2004.09.27

Abstract

Objective We investigated the effect of Saururus chinensis (Lour.) Baill. aquacupuncture (SCB) on anaphylaxis in mice. Methods : We conformed compound 48/80-induced mesenteric mast cell degranulation, active systemic anaphylatic shock and histamine release. Also observed acetic acid-induced vascular permeability and anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis. Results : SCB inhibited mesenteric mast cell degranulation and active systemic anaphylatic shock induced by compound 48/80 dose-dependently. When SCB was pretreated by intra-peritoneal injection, the serum histamine levels were reduced. SCB also significantly inhibited acetic acid-induced vascular permeability. In addition, SCB showed a significant inhibitory effect on anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis. Conclusion : These results indicated that SCB inhibits anaphylatic reaction.