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Effects of Boonsimgieum aqua-acupuncture on Serum and Liver Lipid Composition and Antioxidative Capacity in Rats Fed High Oxidized Fat

분심기음약침(分心氣飮藥針)이 과산화지질(過酸化脂質)을 투여한 흰쥐의 혈장(血漿) 및 간장(肝臟)지질구성과 항산화(抗酸化)에 미치는 영향 -태충혈(太衝穴)과 내관혈(內關穴)을 중심으로-

  • Lee, Jun-Mu (Department of Acupuncture & Meridian, College of Oriental Medicine, Sang-Ji University) ;
  • Kim, Min-Ki (Department of Acupuncture & Meridian, College of Oriental Medicine, Sang-Ji University)
  • 이준무 (상지대학교 한의과대학 경혈학교실) ;
  • 김민기 (상지대학교 한의과대학 경혈학교실)
  • Published : 2004.12.30

Abstract

Effects of Boonsimgieum aqua-acupuncture at $Naegweun(HP_6)$ and $Taecheung(LV_3)$ on liver and plasma lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Concentrations of plasma triglyceride, total cholesterol and LDL-cholesterol showed a tendency to increase in the high oxidized fat diet group. However these values showed a tendency to decease in aqua-acupuncture groups. HDL-cholesterol showed no significantly different in all the treatment groups. Liver total cholesterol values showed a high in control group, however other treatment groups showed no significantly different. Liver triglyceride concentration showed a high value in control group and $Naegweun(HP_6)$ aqua-acupuncture group showed lower value than $Taecheung(LV_3)$ aqua-acupuncture group. Plasma GOT and GPT values showed a tendency to increase in high oxidized fat diet group. However aqua-acupuncture groups showed a lower values than control group. The concentration of TBARS in liver and plasma showed a high values in high oxidized fat diet group, however these values showed a tendency to decrease in aqua-acupuncture group. Glutathione peroxidase, superoxide dismutase and catalase activity values showed a low values in high oxidized fat diet group, however these values showed a tendency to increase in aqua-acupuncture groups and in aqua-acupuncture groups, these values showed no significantly different.

References

  1. 朱震亨. 丹溪心法, 서울, 대성출판사, 1982 : 889
  2. Vergroeson AT. 1997. Physiological effects of dietary linoleic acid. Nutr Rev 35: 1-9.
  3. Saito M. 1988. Interaction between lipid peroxide formation and nutritional status. J JPN Soc Nutr Food Sci 41:343-349.
  4. Bidlack WR, Tappel AL. 1973. Damage to microsomal membrane by lipid peroxidation. Lipids 8 : 177–178.
  5. Younes M, Siegers CP. 1980. Lipid peroxidation as a consequence of glutathione depletion in rat and mouse liver. Res Comm Chem Path Pharm 27 : 119-129.
  6. Langanier S, Yu BP. 1987. Anti-lipoperoxidation action of food restriction. Biochem Biophys Res Comm 145 : 1185-1202. https://doi.org/10.1016/0006-291X(87)91562-2
  7. Choi, M.Y., Cho, E.J., Lee, E. Effects of rhus chinensis gall extract on liver function, plasma lipid composition and antioxidant system in rats with high fat diet. J. Korean Soc. Food Sci. Nutr. 1999. p. 28,pp.632-637.
  8. Kim, MJ., Lee, E., Cha, B.C, Choi, M.Y., Rhim, T.J., and Park, H.J. Serum cholesterollowering effect of triterpene acetate obtained from Latuca indica. Kor. J. Pharmacogn. 1997, p. 28,pp.21-25.
  9. 이은, 최무영, 오혜숙. 시호분말이 과산화지질을 급여한 흰쥐의 혈장 및 간장지질구성에 미치는 영향. 2000,33(5),pp.502-506
  10. 장경자. 타우린과 베타알라딘이 실험적 당뇨유발쥐의 혈당 및 혈중지질농에 미치는 영향. 한국영양학회지. 1999,32(3), pp. 213-220.
  11. 오선진, 김우경, 김양하, 김혜경, 최은혜, 김숙희. 올리고당 첨가식이가 흰쥐의 지질대사에 미치는 영향. 한국영양학회지. 1999,32(2), pp. 129-136.
  12. 오세웅, 침자극이 고지방식이를 급여한 흰쥐의 체지질합성과 항산화능에 미치는 영향. 상지대학교 대학원 박사논문, 2000.
  13. 崔淳暾, 半夏白朮天麻湯이 고지혈증에 미치는 영향. 대전대학교석사학 논문, 1990.
  14. 李大植. 고혈압 및 고지혈증에 대한 淸熱導痰湯의 실험적 연구. 대한 한방내과학회지, 12,16-23, 1991.
  15. 임종국, 애구생체반응의 문헌적 고찰. 동양의학, 1976, 13, 63-68
  16. Buge J A, Aust S D. Microsomal lipid peroxidation. In : Fleicher, S., Packer, L. eds. Methods in enzymelogy (London, Academic press) 52: 302-309, 1978 https://doi.org/10.1016/S0076-6879(78)52032-6
  17. V.Levander O. A, DeLoach D. P, Morris C, Moser P. B. Platelet glutathione peroxidase activity as an index of selenium status in rats. J. Nutr 113 : 55-63, 1983
  18. Flohe L, Becker R. Brigelius R. Lengfelder E. Otting F. Convenient as says for superoxide dismutase. CRC Handbook of free radicals and antioxidants in Biomedicine, 287-293, 1992.
  19. Johnson LH, Hlkan Borg LA. A spectrophtometric method for determination of catalase activity in small tissue samples. Analytical Biochemistry 174, 331-336, 1988. https://doi.org/10.1016/0003-2697(88)90554-4
  20. 汪機 외. 黃帝內經素問今釋, 서울, 성보사, 1983 : 146
  21. 陳士鐸. 石室秘錄, 서울, 대성문화사, 1993 : 98
  22. 傅靑主. 傅靑主男女科. 葉天士女科, 서울, 대성문화사, 1982 : 106
  23. 經京河. 生肝湯이 고지혈증에 미치는 영향. 경희한의대논문집 12, 263-283, 1989.
  24. 이명진. 침자극이 비만쥐의 지질강하 및 항산화효과와 Apo-B, Apo-E, TNF-$\alpha$ 및 Leptin의 DNA발현량에 미치는 영향. 상지대학교 대학원 박사논문, 2002.
  25. 김종흘. 자침이 비만쥐의 혈청지질저하 및 항산화효과와 분자생물학적 양상에 미치는 영향. 상지대학교대학원, 2002.
  26. 정선희. 비만환자의 전침치료 임상예. 대한침구학회지, 1999, 16(3): 39-56
  27. 王其飛. 中醫長壽學. 南京, 遼寧科學技術出版社, 1989; 490-501
  28. 宗文九, 痰飮淺設. 上海, 上海科技, 1985 ; 51-52
  29. 陸紀宏, 試論中醫辮治高脂血症, 遼寧中醫雜誌, 1991 ; 18(2) ; 1-3