Anti-inflammatory and Antinociceptive Activities of 'Coccinia indica W. &A.' Fruit Juice Powder in Animals

  • Rao, GMM (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Rao, Ch V (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Sudhakara, M. (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Pandey, M M (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Rawat, AKS (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Sirwaikar, A (Department of Pharmacognosy, College of Pharmaceutical Sciences) ;
  • Joshi, AB (Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences)
  • 발행 : 2004.02.28


The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by ${\lambda}$ carrageenin (1%) and histamine $(10^{-3}\;g/ml,\;0.1\;ml)$ in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.


  1. Alcaraz, M. J. and Jimenez, M. J., Flavonoids as an antiinflammatoiy agents. Fitoterapia 59, 25-38 (1988)
  2. Castro. J., Saseme, H., Sussman, H. and Bullette, P, Diverse effect of SKF 52 and antioxidants on $CCI_4$ induced changes in liver microsomal P-450 content and ethylmorphme metabolism. Life. Sci. 7 , 129-136(1968)
  3. Chawla, A. S., Singh, M., Murthy, M. S., Gupta, M. P. and Singh, H., Antiinflammatory action of ferulic acid and its esters in carrageenan induced rat paw oedema model. Ind. J. Exp. Biol. 25, 187-189(1987)
  4. Della, L. A., Tubaro, A., Dri, P., Zilli, C. and Del, N. R, The role of flavonoids in the antiinflammatory activity of chamomilla recutita. Clin. Biol. Res. 213, 481-486 (1968)
  5. Di Rosa M., Biological properties of carrageenan. J. Pharm. Pharmacol. 24, 89-102. (1972)
  6. Kirtikar. K. R and Basu. B. D. Indiam Medicinal PIants, Vol II (Lalit Mohan Basu, Allhabad), 1933. pp. 1151-1152
  7. Lino, C. S., Taveira. M. L., Viana, G. S. B., and Matos, F. J. A., Analgesic and antiinflammatory activity of Justicia pectoralis Jacq and its main constituents: Coumarin & Umbelliferone. Phytother. Res. 11, 211-215 (1997)<211::AID-PTR72>3.0.CO;2-W
  8. Miller, L. C. and Tainter, M. L., Evaluation of $ED_50$ and its error by means of logarithmic probit graph papers. Proc. Soc. Exp. Biol. Med. 57, 261-264(1944)
  9. Nadkami, A. K., Indian Materia Medica, Vol. I (Popular Book Depot, Bombay-l), 1954. pp. 300
  10. Parmar, N. S. and Ghosh, M. N., AntiinGammatory activity of Gossypin a bioflavonoid isolated from Hibiscus vitifolius Linn. Indian. J. Pharmacol. 10, 277-293 (1978)
  11. Pillai, N. R., Ghosh, D., Uma, R. and Kumar A., Bull. Med. Ethnobot. Res. 1, 234 (1980)
  12. Shaw, B. P. and Gupta, S., Nagarjun, 25, 24 (1981)
  13. Spadaro., Evidence of correlation between mastcell Histamine and Beta Endorphin from Nil Pitutary in the Homoeostasis. Pharmacol. Res. Comm. 19, 131-136(1987)
  14. Winter, C. A., Risley. E. A. and Nuss, G. W., Carrageenin induced edema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med.lll, 544-547. 1962
  15. Witkin, L.B., Huebner, C.F, Galdi F, OKeefe E, Spitaletta. P. and Plummer, A. J., Pharmacognosy of 2 amino-indane hydrochloride (Su 8629): A potent non-narcotic analgesic. J. Pharmacol. Exp. Therape. 133,400-408(1961)