Action of Asparagus racemosus Against Streptozotocin-Induced Oxidative Stress

  • Govindarajan, Raghavan (Pharmacognosy & Ethnopharmacology Division, National Botanical Research Institute) ;
  • Vijayakumar, Madhavan (Pharmacognosy & Ethnopharmacology Division, National Botanical Research Institute) ;
  • Rao, Chandana Venkateshwara (Pharmacognosy & Ethnopharmacology Division, National Botanical Research Institute) ;
  • Kumar, Vivek (Pharmacognosy & Ethnopharmacology Division, National Botanical Research Institute) ;
  • Rawat, Ajay Kumar Singh (Pharmacognosy & Ethnopharmacology Division, National Botanical Research Institute) ;
  • Pushpangadan, Palpu (Pharmacognosy & Ethnopharmacology Division, National Botanical Research Institute)
  • Published : 2004.08.31


Antidiabetic treatment with tubers of Asparagus racemosus (Liliaceae) extract (l00 and 250 mg/kg body weight) for three weeks showed significant reduction in thiobarbituric acid reactive substances (TBARS) and glutathione reductase (GSH-R) in both liver and kidney. The treatment with A. racemosus significantly altered the glutathione (GSH) and GSH-R to be comparable with the control group. A. racemosus and glibenclamide treated rats showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and Catalase (CAT). The ability of A. racemosus on tissue lipid per oxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that though, A. racemosus possesses moderate antidiabetic activity, but it exhibits potent antioxidant potential in diabetic conditions.


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