Constituents of Mallotus nepalensis Muell. Arg.: a Mild CNS Depressant

  • Rastogi, Subha (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Mehrotra, Bishen Narain (Central Drug Research Institute) ;
  • Kulshreshtha, Dinesh K. (Central Drug Research Institute)
  • Published : 2004.10.30

Abstract

Mallotus nepalensis (Euphorbiaceae) is a small tree found in central and eastern Himalayas, Nepal, Wallich and Sikkim. The 90% ethanolic extract of Mallotus nepalensis exhibited mild CNS depressant activity. Four compounds, lupeol (1), ${\beta}-sitosterol$ (2), ursolic acid (3) and ${\beta}-sitosterol-\;{\beta}-D-glucoside$ (4) were isolated from the 90% ethanolic extract of this plant of which 1, 3 and 4 are being reported for the first time from this species.

References

  1. Hooker, J.D., Ftora of British India, L.Reeve & Co., Ltd, Ashfort, Kent, 1885, Vol. 5, pp. 428-429
  2. Sil, A.K., Som, U.K., and Dutta, C.R, Chemical investigation of Mallotus nepalensis Muell. Indian J. Chem. 19B, 330-331(1980)
  3. Wambebe, C., Influence of some agents that affect 5-hydroxy-tryptamine metabolism and receptors on nitrazepam-induced sleep in mice. Braz. J. Pharmacol. 84, 185-191 (1985)
  4. Willianson, E., Okpako, D., and Evans, F.J., Selection, preparation and pharmacologicat evaluation of plant material. Chichester, Wiley; 1996
  5. Rolland, A., Fleurentin, J., Lanhers, M.C., Younos, C., Misslin, R., Mortier, R, et al. Behavioural effects of the American tra ditional plant Eschscholzia californica: sedative and anxiolytic properties. Planta Med. 57, 212-216 (1991) https://doi.org/10.1055/s-2006-960076
  6. Yun-Choi, H.S., Jin, J.L., Hong, S.W., Lee, Y.Y, and Lee, J.H., Constituents of Euphorbia milli. Nat. Prod. Sciences 9(4), 270-272
  7. Yue, A., Hiroshige, H., Koh, S., Hirotaka, K., Kunio, I., and Takashi, K., Induction of apoptosis by lupeol isolated from mokurnen (Gossampinus matabarica L. Merr) in human pro myelotic leukemia HL-60 cells, Oncology Reports 11, 289-292 (2004)