Constituents of Mallotus nepalensis Muell. Arg.: a Mild CNS Depressant

  • Rastogi, Subha (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Mehrotra, Bishen Narain (Central Drug Research Institute) ;
  • Kulshreshtha, Dinesh K. (Central Drug Research Institute)
  • Published : 2004.10.30


Mallotus nepalensis (Euphorbiaceae) is a small tree found in central and eastern Himalayas, Nepal, Wallich and Sikkim. The 90% ethanolic extract of Mallotus nepalensis exhibited mild CNS depressant activity. Four compounds, lupeol (1), ${\beta}-sitosterol$ (2), ursolic acid (3) and ${\beta}-sitosterol-\;{\beta}-D-glucoside$ (4) were isolated from the 90% ethanolic extract of this plant of which 1, 3 and 4 are being reported for the first time from this species.


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