DOI QR코드

DOI QR Code

The Study on Safety of Scolopendrid Aqua-acupuncture

오공약침(蜈蚣藥鍼)의 안전성(安全性)에 관한 연구(硏究)

  • Lim, Seung-Il (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Kim, Sung-Nam (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • So, Ki-Suk (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Choi, Hoi-Kang (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Lim, Jeong-A (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Lee, Sang-Kwan (Department of Internal Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Moon, Hyung-Cheol (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Soh, Kyung-Sun (College of Oriental Medicine, Semyung University) ;
  • Kim, Sung-Chul (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Won-Kwang University)
  • 임승일 (원광대학교 광주한방병원 침구학교실) ;
  • 김성남 (원광대학교 광주한방병원 침구학교실) ;
  • 소기숙 (원광대학교 광주한방병원 침구학교실) ;
  • 최회강 (원광대학교 광주한방병원 침구학교실) ;
  • 임정아 (원광대학교 광주한방병원 침구학교실) ;
  • 이상관 (원광대학교 광주한방병원 내과학교실) ;
  • 문형철 (원광대학교 광주한방병원 침구학교실) ;
  • 소경순 (세명대학교 한의과대학 예방의학교실) ;
  • 김성철 (원광대학교 광주한방병원 침구학교실)
  • Published : 2004.02.29

Abstract

Objective : Recently scolopendrid aqua-acupuncture has been a good effect on pain control but it has not been known about clinical safety. The purpose of this study was to investigate acute toxicity of scolopendrid aqua-acupuncture. Method : In order to prove the clinical safety of scolopendrid aqua-acupuncture, We have observed a bacteriological examination and clinical pathology test after scolopendrid aqua-acupuncture treatment. Balb/c mice were injected intravenous with Scolopendrid aquaacupuncture treatment for $LD_{50}$ and acute toxicity test. We analyzed physical reaction(side effect)and clinical pathology test before and after Scolopendrid aqua-acupuncture treatment of mice and 20 patients suffering from pain, who admitted department of Acupunture and Moxibustion, College of Oriental Medicine, Won-Kwang University Kwangju hospital. Results : In the Blood agar plate and Nutrient agar plate, a bacteriological examination did not show a bacillus. In acute $LD_{50}$ toxicity test, there was no mortality thus unable to attain the value. Examining the toxic response in the acute toxicity test, there was no sign of toxication. In acute toxic test, running biochemical serum test couldn't yield any differences between the control and experiment groups. In the 20 patients treated with Scolopendrid aqua-acupuncture, hematologic test did not show remarkable change. In the 20 patients treated with Scolopendrid aqua-acupuncture, Liver function test(AST, ALT, ALP) showed a slight decrease on the contrary, and abnormal rate showed a decrease of 5.0% compared with previous study. Reanl function test(BUN, Cr) and abnormal rate showed a decrease of 5.0% compared with previous study. In the 20 patients treated with Scolopendrid aqua-acupuncture, Electrolyte were normal range before and after treatment. In the Urine analysis of 20 patients, Leukocyte, Protein, Glucose, Keton, Bilirubin, U-bilinogen were not detected before and after Scolopendrid aqua-acupuncture treatment, and the rest almost made no difference.

References

  1. 대한약침학회 : 약침요법시술서(II). 서울, 대한약침학회,pp. 13-62, 2000.
  2. 전국한의과대학 침구경혈학교실 : 침구학(하), 서울, 집문당, p. 1457. 1998.
  3. 吳普 : 神農本草經, 서울, 醫道韓國社, 3권 : 28, 1987.
  4. 李時珍 : 本草綱目(下). 北京, 人民衛生出版社, pp. 2345-2349, 1982.
  5. 時逸人 : 中國藥物學. 台聯國風出版社, pp. 404-405, 1983.
  6. 홍남두 : 경희약대논문집, Vol 5 : 20-27, 1977.
  7. 上海中醫學院 : 中草藥學. 上海, 商務印書館香港分官出版, pp. 347-348. 1975.
  8. 이상인 : 본초학. 서울, 수서원, pp. 239-240, 1975.
  9. 하지광 : 신중국한의학. 대구, 용성출판사, pp. 270-271, 1995.
  10. 이상인, 신민교 외 : 한약임상응용. 서울, 성보사, pp.441-442, 1990.
  11. 정병태, 장경전, 송춘호, 안창범 : 蜈蚣수침이 진통 및 진경효과에 미치는 영향. 대한침구학회지, 14(2) : 219-230, 1997.
  12. 고강훈, 박소영, 최회강, 소기숙, 황우준, 이건목, 김성철 : 오공약침을 이용한 요추간판탈출증 치료의 임상적 연구, 대한침구학회지, 19(3) : 192-206. 2002.
  13. 최회강, 소기숙, 고강훈, 박소영, 김성남, 이종덕, 원경숙, 문형철, 김성철 : 추적조사를 중심으로 한 요추추간판탈출증에 대한 오공약침의 임상적 연구, 대한침구과학회지, 20(3) : 238-252. 2003.
  14. 강계성 외 : 홍화약침의 부작용에 관한 임상적 고찰, 대한약침학회지, 2: 65-72, 2001. https://doi.org/10.3831/KPI.2001.4.2.065
  15. 대한약침학회 : 약침제재와 임상응용(I), 서울, 대한약침학회 출판부, pp. 227, 1997.
  16. 김경식 : 동의임상지침, 서울, 대성문화사, pp. 167-168, 214-221, 253-257.1998.
  17. 임사비나 : 약침의 안전성 및 안정성 연구의 의미와 방향, 대한약침학회 국제학술대회 논문집, 4(1) : 47, 2001.
  18. 신민교 : 원색 임상본초학, 서울, 남산당, p.665. 1986.
  19. 박소영, 고강훈, 소기숙, 최회강, 오희홍, 김일두, 박상준, 안수기, 김성철 : 오공에 대한 문헌적 고찰, 5(1) : 53-59, 2002. https://doi.org/10.3831/KPI.2002.5.1.053
  20. 박영준 : 한방동물보감, 서울, 푸른물결, p. 154. 2000.
  21. 陣貴廷 : 本草綱目通釋. 北京, 學苑出版社, pp. 1898-1890, 1992.
  22. 김종희 : 오공의 진통, 소염, 진경 및 독성작용에 관한 실험적 연구, 대전대학교석사학위논문, pp. 1-22, 1991.
  23. 楊倉良 等 : 毒藥本草. 中國中醫藥出版社, p.721, 1993.
  24. 常毅敏 : 抗癌本草. 서울, 바람과 물결, p.446, 1992.
  25. 楊更生 : 蟲類藥的不良反應與防治. 新中醫, 8 : 52-54, 1989.
  26. 余聖龍 : 生蜈蚣致過敏. 中國中藥雜誌, p. 56. 1989.
  27. 대한임상의학연구소 : 임상병리파일 2. 서울, 의학문화사, p.16, 1996.
  28. 대한임상병리학회 : 임상병리학 2. 서울, 고려의학, pp. 67-100, 119-132, 1996.
  29. 식품의약품안전본부 : '의약품 독성시험기준' 제 98-116호. 1996.

Cited by

  1. A Pilot Study on Single-dose Toxicity Testing of Scolopendrid Pharmacopuncture in Sprague-Dawley Rats vol.17, pp.2, 2014, https://doi.org/10.3831/KPI.2014.17.017
  2. Single Dose Toxicity of Chukyu (spine-healing) Pharmacopuncture Injection in the Muscle of Rats vol.17, pp.1, 2014, https://doi.org/10.3831/KPI.2014.17.005