Comparison of Ginsenoside Composition and Contents in Fresh Ginseng Roots Cultivated in Korea, Japan, and China at Various Ages

수삼의 지역별 연근별 인삼사포닌 함량 비교

  • 이충렬 (중앙대학교 인삼산업연구센터) ;
  • 황완균 (중앙대학교 약학대학) ;
  • 신차균 (중앙대학교 생명공학과) ;
  • 이학성 (중앙대학교 생명공학과) ;
  • 한성태 (중앙대학교 생명공학과) ;
  • 임병옥 (중앙대학교 인삼산업연구센터) ;
  • 고성권 (중앙대학교 인삼산업연구센터)
  • Published : 2004.10.31


Cooking basic information for indexing of fresh ginseng roots (Panax ginseng C. A. Meyer) was determined. Ginsenoside contents of various age fresh ginseng roots cultivated in Northeast Asia were quantitatively analyzed by HPLC. Average contents of total saponin and each ginsenoside of 4-year-old fresh ginseng root cultivated in Korea were higher than those cultivated fur longer periods (5- and 6-year-old). One-way analysis variance showed average contents of total saponin and each ginsenoside of 4-, 5-, and 6-year-old fresh ginseng roots were not statistically significant. Four-year-old fresh ginseng root cultivated at Geumsan, Korea contained the highest ginsenoside content among samples studied.


  1. Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tonooka S, Samukawa K, Azuma I. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside- Rg$_3$, of red ginseng. Biol. Pharm. Bull. 18: 1197-1202 (1995)
  2. Wang BX, Cui JC, Liu AJ, Wu SK. Studies on the anti-fatigue effect of the saponins of stems and leaves of Panax ginseng (SSLG). J. Tradit. Chin. Med. 3: 89-94 (1983)
  3. Park JD. Recent studies on the chemical constituents of Korean Ginseng (Panax ginseng C.A. Meyer). Korean J. Ginseng Sci. 20: 389-415 (1996)
  4. Jang JG, Lee KS, Kwon DW, Nam KY, Choi JH. Study on the changes of saponin contents in relation to root age of Panax ginseng. Korean J. Food Nutr. 12: 37-40 (1983)
  5. Kim MW, Ko SR, Choi KJ, Kim SC. Distribution of saponin in various sections of Panax ginseng root and changes of its contents according to root age. Korean J. Ginseng Sci. 11: 10-16 (1987)
  6. Shibata S, Tanaka T, Ando T, Sado M, Tsushima S, Ohsawa T. Chemical studies on oriental plant drugs (XIV). Protopanaxadiol, a genuine sapogenin of ginseng saponins. Chem. Pharm. Bull. 14: 595-600 (1966)
  7. Chung HB, Lee CB, Yoon SW, Lee JH, Choi S, Ko SK, Park H, Lim BO. Strategies of Globalization for Ginseng Industry. Ijin Publishing, Seoul, Korea (2003)
  8. Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb$_2$ in streptozotocin-diabetic rats. Chem. Pharm. Bull. 33: 869-872 (1985)
  9. Jeong CS, Hyun JE, Kim YS. Anti-oxidative effect of ginsenoside $Rb_1$ on the HC1 . ethanol-induced gastric tissue in rats. Korean J. Pharmacogn. 33: 252-256 (2002)
  10. Jung IS, Cho YD. Effect of ginseng saponin fraction on absorption of cholesterol and serum lipid components. Korean J. Ginseng Ginseng Sci. 9: 232-239 (1985)
  11. Ko SK, Lee CR, Choi YE, Im BO, Sung JH, Yoon KR. Analysis of ginsenosides of white and red ginseng concentrates. Korean J. Food Sci. Technol. 35: 536-539 (2003)
  12. Saito H, Yoshida Y, Tagaki K. Effects of Panax ginseng root on exhaustive exercise in mice. Jpn J. Pharmacol. 24: 119-126 (1974)
  13. Namba T. The Encyclopedia of Wakan-Yaku with Color Pictures. Hoikusha, Osaka, Japan (1980)
  14. Matsuda H, Samukawa K, Kubo M. Anti-hepatitic activity of ginsenoside Ro. Planta Med. 57: 523-526 (1991)
  15. Sanata S, Kondo N, Shoji J, Tanaka O, Shibata S. Studies on the saponins of ginseng. I. Structure of ginsenoside-R$_0, Rb_1, Rb_2,$ Rc and Rd. Chem. Pharm. Bull. 22: 421-428 (1974)
  16. Yoon SH, Joo CN. Study on the preventive effect of ginsenosides against hypercholesterolemia and its mechanism. Korean J. Ginseng Sci. 17: 1-12 (1993)
  17. Matsuda H, Samukawa K, Kubo M. Anti-inflammatory activity of ginsenoside Ro. Planta Medica. 56: 19-23 (1990)
  18. Ko SR, Choi KJ, Kim SC, Han KW. Content and composition of saponin compounds of Panax species. Korean J. Ginseng Sci. 19: 254-259 (1995)
  19. Namba T, Yoshizaki M, Tomimori T, Kobashi K, Mitsui K. Chemical and biochemical evaluation of ginseng and related crude drugs. Yakugaku Zasshi. 94: 252-260 (1974)