Anticancer Effect of Erythronium japonicum Extract on ICR Mouse and L1210 Cells with Alteration of Antioxidant Enzyme Activities

얼레지 추출물의 ICR 마우스와 L1210 암세포에 대한 항암작용과 그에 따른 항산화효소 활성변화

  • Shin, Yoo-Jin (Department of Chemistry, Sangmyung University) ;
  • Jung, Dae-Young (Department of Herbal Pharmaceutical Medicine, Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyung (Department of Chemistry, Sangmyung University) ;
  • Park, Sie-Won (Department of Chemistry, Sangmyung University)
  • 신유진 (상명대학교 화학과) ;
  • 정대영 (한국 한의학 연구원 한약제재 개발부) ;
  • 하혜경 (상명대학교 화학과) ;
  • 박시원 (상명대학교 화학과)
  • Published : 2004.12.31

Abstract

Effects of Erythronium japonicum methanol extract on ICR mouse with induced abdominal cancer and L1210 cells were studied. Administration of methanol extract ($10-100\;{\mu}g/20\;g$ body weight) prolonged life by 47.8% and decreased number of L1210 cells with $IC_{50}\;of\;54.6\;{\mu}g/mL$ after 3 days culture, whereas little effect was observed against normal lymphocytes (<6% compared to 83.2% of L1210 cells under the same condition). Increased SOD and GPx enzyme activities, and remarkably augmented generation of ${O_2}^-$ ion in L1210 cells by E. japonicum extract, implied that reactive oxygen species including ${O_2}^-$ ion, might have participated in L1210 cell death

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