Induction of Nitric Oxide and Cytokines in Macrophages by Codonopsis lanceolata

대식세포에서 산더덕에 의한 NO 생성 및 싸이토카인 유도효과

  • So, Mi-Sun (Microbia Corp. Limited Technical Research Institute) ;
  • Lee, Jin-Sil (Foodservice Management Nutrition, Sangmyung University) ;
  • Yi, Seh-Yoon (Department of Chemistry, Suwon University)
  • 소미선 ((주)마이크로비아 기술연구소) ;
  • 이진실 (상명대학교 외식영양학과) ;
  • 이세윤 (수원대학교 화학과)
  • Published : 2004.12.31


The immunomodulatory effect of Codonopsis lanceolata based on the production of cytokines and the activation of macrophage was studied. The mRNA expression of nitric oxide synthase (iNOS) was gradually induced after 24 hr treatment of Codonopsis lanceolata, and NO production was a maximum after 24 hr treatment with 1 mg/mL. RAW 264.7 cell on in vitro treatment with Codonopsis lanceolata induced mRNA of cytokines such as interleukin-1(IL-1)${\beta}$, interleukin-6(IL-6), tumor necrosis $factor(TNF)-{\alpha}\;and\;interferon(IFN)-{\gamma}$; $IL-1{\beta}$ and IL-6 mRNA were gradually induced up to 24 hr, $TNF-{\alpha}\;mRNA$ was regularly induced up to 24 hr, and $IFN-{\gamma}\;mRNA$ level was a maximum within 1 hr. These results suggest that Codonopsis lanceolata exerts as an effective immunomodulator and enhances antitumor activity of macrophages.


Codonopsis lanceolata;activated macrophage;immunomodulator


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