Effect of Intestinal Function Enhancer (KTG075) on Mucin 2 Secretion

장기능개선제-신소재(KTG075)의 대장관 내 mucin 2 분비에 미치는 영향

  • Published : 2004.12.31


Effects of formulation KTG075 from edible plants on intestinal function, particularly on Mucin 2 secretion, were examined by loperamide-induced constipation method using Sprague Dawley rats (SD rats, male). Crypt epithelial cells containing more mucus and mucus layer stained with alcian blue were significantly thicker in KTG075 group than control group. When Biogenex AM358 of antibody against Mucin 2 was used, crypt epithelial cells secreted more Mucin 2 in KTG075 group than control group. The Mucus layer at fecal surface was thinner and less mucus was recovered from mucosal surface in constipated rats than in KTG075 group. Mucus production of crypt epithelial cells and mucus contents at fecal and mucosal surfaces were reduced by loperamide-induced constipation. These results indicate formula KTG075 accelerates evacuation and activates intestines.


intestinal function;improving agent constipation;loperamide-induced constipation method;charcoal meal transit;KTG075;mucus layer;mucin;mucin 2


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