Comparative pharmacokinetics of norfloxacin-glycine acetate after single oral administration and medication with drinking water in broilers

  • Lim, Jong-hwan (College of Veterinary Medicine, Chungnam National University) ;
  • Lim, Byoung-yong (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Byung-kwon (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myong-seok (College of Veterinary Medicine, Chungnam National University) ;
  • Jang, Beom-su (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Seung-chun (College of Veterinary Medicine, Kyungpook National University) ;
  • Yun, Hyo-in (College of Veterinary Medicine, Chungnam National University)
  • Accepted : 2004.04.02
  • Published : 2004.06.30

Abstract

Norfloxacin (NFX) is a fluorquinolone antibacterial agent with a high antimicrobial activity and might have great potential for treating common infections in poultry. The objective of this study was to obtain comparative pharmacokinetic data after a single oral administration and medication with drinking water of norfloxacin-glycine acetate (NFX-GA) at the dose rate of 10 mg/kg bw in broilers. Fifty minutes following oral administration of NFX-GA, serum concentrations peaked at $1.32{\mu}g/mL$ (range $1.03-1.45{\mu}g/mL$). Serum concentration of NFX declined with a half-life of $7.21{\pm}1.81$ h. On the third day after administration of medicated drinking water, steady-state was reached, with mean concentrations of NFX of $0.70{\pm}0.35{\mu}g/mL$. The concentration of NFX after medication of NFX-GA with drinking for 3 days provides sufficient levels to obtain maximum therapeutic effects and maintains the serum persistence of concentration exceeding MIC.

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