Morphological evaluation on the effect of panaxadiol series ginsenosides in irradiated mice

방사선 조사 마우스에서 인삼 panaxadiol계 ginsenosides의 효과에 관한 형태학적 평가

  • Lee, Hae-june (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Se-ra (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Sung-ho (College of Veterinary Medicine, Chonnam National University)
  • Accepted : 2004.05.10
  • Published : 2004.06.30

Abstract

The purpose of the study was to investigate the effect of ginseng saponins (panaxadiol, ginsenoside $Rb_1$, $Rb_2$, Rc, Rd) on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with gamma-ray. ICR mice were given each saponin (i.p. 50 mg/kg of body weight) at 24 hours before irradiation. The radioprotective effects of saponins were compared with the irradiation control respectively. The jejunal crypts were protected by pretreatment with ginsenoside Rc (p<0.05) and Rd (p<0.05). The spleen colony was increased by pretreatment with panaxadiol (p<0.05) and ginsenoside Rd (p<0.05). And the frequency of radiation induced apoptosis was significantly reduced by pretreatment with panaxadiol (p<0.05), ginsenoside Rb2 (p<0.05), Rc (p<0.05) and Rd (p<0.01). These results suggest that ginsenoside Rc, Rd might have a major radioprotective effect.

Acknowledgement

Supported by : 과학기술부

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