Pulmonary adenocarcinoma with brain metastasis in a Miniature Pincher

미니어쳐 핀셔에서 신경증상을 동반한 폐션암

  • Kang, Min-Soo (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Kwon, Hyo-Jung (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Park, Mi-Sun (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Youn, Hwa-Young (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Han, Man-Gil (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Kim, Dae-Yong (College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
  • 강민수 (서울대학교 수의과대학 농생명공학사업단) ;
  • 권효정 (서울대학교 수의과대학 농생명공학사업단) ;
  • 박미선 (서울대학교 수의과대학 농생명공학사업단) ;
  • 윤화영 (서울대학교 수의과대학 농생명공학사업단) ;
  • 한만길 (서울대학교 수의과대학 농생명공학사업단) ;
  • 김대용 (서울대학교 수의과대학 농생명공학사업단)
  • Accepted : 2004.10.22
  • Published : 2004.12.30

Abstract

A 13-year-old female Miniature Pincher was euthanized after suffering from respiratory insufficiency and seizure. At necropsy, firm tan masses approsimately 4 to 5 cm in diameter were noted at the right caudal love and left cranial lobe of the lung. On cross sections of the cerebellum and the verebrum, several compressive firm round masses, 0.5 to 1 cm in diameter, were noted. similar looking nodules were also present in the mediastinal lymph nodes. Histopathologically, the neoplastic masses consisted of cuboidal shape epithelial cells that form glandular structure. The neoplastic cells have hyperchromatic nuclei with prominent nucleoli and moderate amount of cytoplasm. The degree of mitosis was high (4-6/400X). Multiple areas of necrosis, hemorrhage, and tumor emboli were also noted. Metastasis to the mediastinal lymph nodes, pancreas, and brain was confirmed. Based on the gross and histopathologic examinations, a diagnosis of primary metastatic pulmonary adenocarcinoma was made. Clinicaly recognized neurological signs were therefore due to brain metastasis.

Acknowledgement

Supported by : 수의과학연구소

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