Magnetic resonance imaging characteristic of lymph nodes: Comparison of T1 and T2 weighted image in normal rabbits

림프절의 자기공명영상의 특징: 가토에서 T1과 T2 강조영상의 비교

  • Lee, Ki-chang (College of Veterinary Medicine, Seoul National University) ;
  • Choi, Min-cheol (College of Veterinary Medicine, Seoul National University) ;
  • Choi, Ho-Jung (College of Veterinary Medicine, Seoul National University) ;
  • Yoon, Jung-hee (College of Veterinary Medicine, Seoul National University) ;
  • Choi, Seong-hong (College of Medicine, Seoul National University) ;
  • Moon, Woo-kyung (College of Medicine, Seoul National University) ;
  • Chung, Jin-Wook (College of Medicine, Seoul National University)
  • Accepted : 2004.04.25
  • Published : 2004.06.30

Abstract

The detection of lymph node metastasis is an important step in tumor staging and is significant for therapy planning. It has been challenged to yield an appropriate image with diagnostic methods such as Magnetic Resonance (MR) and Computed Tomography (CT). Though CT has been used widely and accessed easily to show internal organs, it can hardly provide difference between lymph node and adjacent vessel or fat tissue. It has been well established that MR can reveal the subtle discrepancy within soft tissue. This study investigated the suitability of MR lymph node imaging without contrast enhancement by comparison of T1-weighted image (T1WI) and T2- weighted image (T2WI) in ten normal rabbits. According to the pulse sequence optimized from preliminary study, T1-weighted spin-echo (repetition time/echo time=400/12 ms) and T-2 weighted fast spin-echo (repetition time/echo time=3500/84 ms) images covering the hind limbs and pelvic region were acquired at 1.5 T. Two radiologists scrupulously evaluated the MR images in consensus. And signal intensity of lymph nodes was compared with that of adjacent fat. Statistical analysis showed that T1-weighted coronal image visualized the lymph nodes (iliac, superficial inguinal and popliteal lymph nodes) quickly and consistently rather than T2-weighted one. Conclusively, T1WI for evaluation of lymph nodes is moderately better than T2WI and appears to have potential for quick and sufficient mapping of the lymph nodes. In addition, this normal MR image of lymph nodes could be applied to further study for the evaluation of lymphatic system in abscess and tumor bearing animal model.

References

  1. 김명진 역. 수학공식없이 읽는 자기공명영상의 원리, 고려의학, 2000
  2. 박일영, 권달관, 홍시영, 조준석. 자기공명영상학, 청구문화사, 1993
  3. Demas, B., Thurnher, S. and Hricak. The kidney, the adrenal gland, and retroperitoneum. In ; Higgins CB, Hricak H (eds). Magnetic resonance imaging of the body, pp 373-402, Raven, New York, 1987
  4. Dooms, G. C., Hricak, H., Crooks, L. E. and Higgins, C. B. Magnetic resonance imaging of the lymph nodes : comparison with CT. Radiology. 1984, 153, 719-728
  5. Grenier, P. Thorax. In: Vanel D and McNamara MT (eds). MRI of the Body, pp 85-114, Springer-Verlag, Paris. 1989
  6. Herborn, C. U., Lauenstein, T. C., Vogt, F. M., Lauffer, R. B., Debatin, J. F. and Ruehm, S. G. Interstitial MR lymphography with MS-325: characterizationof normal and tumor-invaded lymph nodes in a rabbit model. AJR Am J Roentgenol. 2002, 179, 1567-1572
  7. Lavayssiere, R., Cabee, A. E. and Parienty, R. A. Retroperitoneal adenopathy. In: Vanel D and McNamara MT (eds). MRI of the Body, pp 219-221, Springer-Verlag, Paris. 1989
  8. Lee, J. K. T., Heiken, J. P., Ling, D., Glazer, H. S., Balfe, D. M., Levitt, R. G., Dixon, W. T. and Murphy, W. A. Magnetic resonance imaging of abdominal and pelvic lymphadenopathy. Radiology. 1984, 153, 181-188
  9. MacCarthy, S. MRI offers first look into pelvic anatomy. Diagn Imag Clin Med. 1987, 8, 100-106
  10. Ruehm, S. G., Corot, C. and Debatin, J. F. Interstitial MR lymphography with a conventional extracellular gadolinium-based agent: assessment in rabbits.Radiology. 2001, 218, 664-669
  11. Shimada, M., Yoshikawa, K., Suganuma, T., Kayanuma, H., Inoue, Y., Ito, K., Senoo, A. and Hayashi, S. Interstitial magnetic resonance lymphography:comparative animal study of gadofluorine 8 and gadolinium diethylenetriamine-pentaacetic acid. J Comput Assist Tomogr. 2003, 27, 641-646
  12. Sternbrich, W., Beyer, D. and Modder, U. Malignant lymph nodes diseases, diagnosis with MRI in comparison with other imaging modalities. Radiologe.1985, 25, 199-205
  13. Wagner, S. Benign lymph node hyperplasia and lymph node metastases in rabbits. Animal models for magnetic resonance lymphography. Invest Radiol. 1994, 29, 364-371
  14. Zirisnky, K. Y. H., Rubenstein, W. A., Kneelnad, J. B., Whalen, J. P. and Kazam, E. Portacaval space: CT with MR correlation. Radiology. 1985, 156, 453-460