Toxicity study of GC-100X in rats and beagles

랫드와 비글에서 GC-100X 세정제의 독성에 대한 연구

  • Kang, Kyung-Sun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Cho, Sung-Dae (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Ahn, Nam-Shik (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Jung, Ji-Won (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Yang, Se-Ran (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Park, Joon-Suk (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Park, Ki-Soo (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Hong, In-Sun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Seo, Min-Soo (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Jo, Eun-Hye (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Nguyen, Ba Tiep (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Yong-Soon (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
  • 강경선 (서울대학교 수의대학교 공중보건학교실) ;
  • 조성대 (서울대학교 수의대학교 공중보건학교실) ;
  • 안남식 (서울대학교 수의대학교 공중보건학교실) ;
  • 정지원 (서울대학교 수의대학교 공중보건학교실) ;
  • 양세란 (서울대학교 수의대학교 공중보건학교실) ;
  • 박준석 (서울대학교 수의대학교 공중보건학교실) ;
  • 박기수 (서울대학교 수의대학교 공중보건학교실) ;
  • 홍인선 (서울대학교 수의대학교 공중보건학교실) ;
  • 서민수 (서울대학교 수의대학교 공중보건학교실) ;
  • 조은혜 (서울대학교 수의대학교 공중보건학교실) ;
  • ;
  • 이영순 (서울대학교 수의대학교 공중보건학교실)
  • Accepted : 2004.02.10
  • Published : 2004.03.31

Abstract

Because cleaning products are part of our everyday lives, it is essential that they should not present significant risks to health. However, many petrochemicals in most soaps and detergents can be absorbed through the scalp and skin and, over time, accumulate in the organs and tissues. This accumulation may result in brain, nerve, and liver damage. Therefore, it is interested in developing non-harmful detergent. According to Korea Research Institute of Chemical Technology, GC-100X may be non-harmful and non-corrosive alkaline ionic water (pH 12). It is composed of hydroxyl radicals and supplemented with xylitol. To evaluate influence of GC-100X on rats and beagles, GC-100X was diluted with distilled water (25%, 50%, and 100% solution respectively). Each of diluted GC-100X was daily treated per oral. In body weight analysis, urinary analysis, ophthalmological test and autopsy, we did not find any significance, but in serum biochemical analysis and hematological analysis, we found some significances in middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by GC-100X, because it was not found to be significant from control group in histopathological examination. Thus, it is concluded that NOEL(No Observed Effect Level) of GC-100X may be higher than all treatment doses used in this study, and GC-100X may be a non-toxic detergent.

References

  1. 구석진. 계면활성제의 안정성에 대한 고찰. 한국환경 독성학회지. 1990, 5, 1-2
  2. http://www.seowon.co.kr/data/hka04.html
  3. http://www.koreacleaningnews.com/environment/haitai_environment2.htm
  4. http://user.chollian.net/~kasac/images2/poto/sa/s047.html
  5. Miura, Y., Hisaki, H., Fukushima, B., Nagai, T. and Ikeda, T. Detergent induced changes in serum lipid composition in rats. Lipids. 1989, 24, 915-918
  6. Robin Graham-Brown. Soaps and Detergents in the Elderly. Clin. Dermatol. 1996, 14, 85-87
  7. Ronnni Wolf. Soaps, shampoos, and detergents: a scientific soap opera. Clin. Dermatol. 1996, 14, 1-2
  8. Yamamoto, K. Soaps and detergents in children. Clin. Dermatol. 1996, 14, 81-84
  9. Friedman, M. and Wolf, R. Chemistry of soaps and detergents: various types of commercial products and their ingredients. Clin. Dermatol. 1996, 14, 7-13
  10. Becker, S. and Berhane, K. A meta-analysis of 61 sperm count studies revisited. Fertil. Steril. 1999, 67, 1103-1108
  11. 권남훈, 박용호. GC-100X의 주요 식품위해 미생물에 대한 향균효과와 토마토 표면에 부착된 Escherichia coli O157:H7에 대한 세척 효과. 한국식품위생안전성학회지. 2002, 17, 36-44
  12. Steven E. Crow and Sally O. Walshaw. Manual of Clinical Procedures in the Dog Cat, and Rabbit. pp. 66-72, Lippincott, Oxford, 1997
  13. 식품의약품안전청 국립독성연구소. 의약품의 독성시험 기준해설. pp. 28-34, 식품의학품안전청, 서울, 1999