Effect of Certain Immunomodulators on Uterine Infections and Fertility in Post Partum Buffaloes

  • Kumar, Puneet (Indian Veterinary Research Institute) ;
  • Srivastava, S.K. (Indian Veterinary Research Institute) ;
  • Rawat, Mayank (Indian Veterinary Research Institute) ;
  • Yadav, M.C. (Indian Veterinary Research Institute) ;
  • Kumar, H. (Indian Veterinary Research Institute)
  • Received : 2003.06.20
  • Accepted : 2004.04.12
  • Published : 2004.07.01


The present study was aimed to study the effect of aqueous extract of Tinospora cordifolia and autologous plasma on uterine infections. Buffaloes in estrus, 40 days and above postpartum were checked for uterine infections. Animals having uterine infections were randomly divided into three groups of six animals each. Buffaloes in group I, II and III (control) were given intrauterine infusion of aqueous extract of Tinospora cordifolia (3,000 mg total dose), autologous plasma (150 ml) and phosphate buffer saline (150 ml) respectively, in three divided doses, once daily for three consecutive days, starting from the day of estrus. A fourth group (IV) comprising of six buffaloes having no uterine infection was also included in the present study. Buffaloes were inseminated artificially on next estrus following treatment and confirmed for pregnancy 60 days later. Bacterial population in CVM of buffaloes in group I, II and III was significantly (p<0.05) higher than group IV. After treatment there was a significant (p<0.01) reduction in bacterial population in group I (83.496$\pm$7.755%) and group II 80.233$\pm$5.799%) than group in III 7.557$\pm$33.551%) at next estrus. There was non-significant improvement in first service conception rate (CR, 33.33%) and overall conception rate (OCR, 27.27%) in group I, in comparison to group III (first service CR-16.67%; OCR-20.0%). No significant improvement was seen in OCR (22.22%) in-group II also in comparison to group III. The improvement in group I was however, nonsignificantly lower than normal animals of group IV (First service CR-16.67%; OCR-36.33%).


Buffaloes;Uterine Infection Tinospora cordifolia;Autologous Plasma;Bacterial Load;Conception Rate


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