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Antitumor and Antimutagenic Effect of the Proteinpolysaccharides from Polyporus umbellatus

저령다당체의 항종양 및 항돌연변이 효능

  • 이정화 (부산대학교 분자생물학과) ;
  • 신유진 (동서대학교 식품생명공학) ;
  • 조덕제 (동서대학교 식품생명공학) ;
  • 임희진 (동서대학교 식품생명공학) ;
  • 최원일 (대우약품 (주) ;
  • 이용규 (동서대학교 식품생명공학과)
  • Published : 2004.03.01

Abstract

The proteinpolysaccharides (PPS) from Polyporus umbellatus (P. umbellatus) screlotium is composed by 78.2% of saccharide, 16.8% of protein, and 4.0% of ash. PPS from P. umbellatus showed antitumor activities against 180 solid tumor in ICR mice at the concentration of 20-160 mg/kg/day. PPS from P. umbellatus inhibited cell viability to 47.4% and 45.0% in leukemia cell lines, L-1210 and K-562 cells at 50-400 $\mu\textrm{g}$/mL concentration, respectively. But the hall mark of cell apoptosis, DNA fragmentation was not observed at those concentration. 2.5-10.0% of PPS from P. umbellatus inhibited mutagenecity evoked by 2-nitrofluorene and sodium azide in Salmonella typhimurium TA 98 and TA 100. From these results, it is suggested that the PPS of P. umbellatus has antitumor and antimutagenic effect, and its cytotoxic effect may not be ascribed to the apoptosis.

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