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Effects of Dietary Factors on Lymphocyte DNA Damage in Smoking Elderly People in Korea

식이 요인이 SCE 빈도수로 본 흡연노인 임파구 DNA손상에 미치는 영향

  • 강명희 (한남대학교 식품영양학과) ;
  • 이정희 (천안외국어대학 외식산업과)
  • Published : 2004.03.01

Abstract

The spontaneous frequency of genetic damage and the possible relationship of this damage to dietary and nutritional variables were investigated in peripheral blood lymphocytes from 45 elderly people using sister chromatid exchange (SCE). The relationship of dietary and nutritional factors on SCE was assessed by different degrees of smoking status such as smokers (n=14), ex-smokers (n=16) and non-smokers (n=15). Significant relationship of the SCE frequency to nutrient intake of the combined subjects (n=45) was found. When cigarette smoking status was taken into account, there were negative linear relationships between SCE and fat, phosphorus or vitamin A intakes of the non-smokers as well as SCE and the dietary quality scores. There was a positive linear relationship between SCE and food frequency of meat and fish among the smokers. Use of artificial sweetners in ex-smokers of the elderly people produced a significant increase of SCE in comparison with the mean SCE for those not using sweetners. Other dietary parameters, including intake of coffee, green tea and ginseng tea, alcohol consumption, use of processed foods, and administration of vitamin pills did not show any correlation with SCE. These results suggested that dietary fat, phosphorus or vitamin A status are the major determinants of spontaneous DNA damage in lymphocytes of the elderly people.

References

  1. Weisburger JH. 1979. On the etiology of gastro-intestinal tract cancers with emphaisis on dietary factors. In Environmental carcinogenesis. Emmelot P, Kriek E, eds. Elsevier/North-Holland Biomedical Press, Amsterdam. p 215-240
  2. Doll R, Peto R. 1981. The causes of cancer: Quantitative estimates of avoidable risks of cancer in United States to-day. J Natl Cancer Inst 66: 1192-1308.
  3. Committee on Diet, Nutrition, and Cancer, NRC. 1982. Diet, Nutrition, and Cancer. National Academy Press, Washington, DC.
  4. Halliwell B. 1996. Antioxidants in human health and disease. Annu Rev Nutr 16: 33-50 https://doi.org/10.1146/annurev.nu.16.070196.000341
  5. Strain JJ, Hannigan BM, McKenna PG. 1991. The pathophysiology of oxidant damage. J Biomed Sci 2: 19-24.
  6. Anderson D, Jenkinson PC, Dewdney RS, Francis AJ, Godbert P, Butterworth KR. 1988. Chromosome aberrations, mitogen-induced blastogenesis and proliferative rate index in peripheral lymphocytes from 106 control individuals of the U.K. population. Mutation Res 204: 407-420. https://doi.org/10.1016/0165-1218(88)90037-7
  7. Kang MH, Genser D, Elmadfa I. 1997. Increased sister chromatid exchanges in peripheral lymphocytes of patients with Crohn's disease. Mutation Research 381: 141-148. https://doi.org/10.1016/S0027-5107(97)00161-9
  8. Livingston GK, Cannon LA, Bishop DT, Johnson P, Fineman RM. 1983. Sister chromatid exchange: Variation of age, sex, smoking, and breast cancer status. Cancer Genet Cytogenet 8: 289-299.
  9. Hirsch BA, Sentz KK, McGue M. 1992. Genetic and environmental influences on baseline SCE. Envion Mol Mutagen 20: 2-11 https://doi.org/10.1002/em.2850200103
  10. Bonase S, Bolognesi C, Abbondandolo A, Barale R, Bigatti P, Camurri L, Dalpra L, De Ferrari M, Forni A, Lando C, Padovani P, Pasquini R, Stella M, Puntoni F. 1995. Influence of sex on cytogenetic end points: evidence form a large human sample and review of the literature. Cancer Epidemiol. Biomarkers Prev 4: 671-679
  11. Barale R, Chelotti L, Vavini T, Del Ry S, Andreassi MG, Ballardin M, Bulleri M, He J, Baldacci S, Di Pede F, Gemignani F, Landi S. 1998. Sister chromatid exchange and micornucleus frequency in human lymphocytes of 1650 subjects in an Italian population. II. Contribution of sex, age and life style. Environ Mol Mutagen 31: 228-242. https://doi.org/10.1002/(SICI)1098-2280(1998)31:3<228::AID-EM4>3.0.CO;2-G
  12. Joenje H. 1989. Genetic toxicology of oxygen. Mutat Res 219: 193-208. https://doi.org/10.1016/0921-8734(89)90001-5
  13. MacGregor, Wehr CM, Hiatt RA, Peters B, Tucker JD, Langlois RG, Jacob RA, Jensen RH, Yager JW, Shigenaga MK, Frei B, Eynon BP, Ames BN. 1997. 'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status. Mutat Res 377: 125-135. https://doi.org/10.1016/S0027-5107(97)00070-5
  14. Cheng T-J, Christiani DC, Xu X, Wain JC, Wiencke JK, Kelsey KT. 1995. Glutathione S-transferase $\mu$ genotype, diet, and smoking as determinants of sister chromatid exchange frequency in lymphocytes. Caner Epidemiol Biomarkers Prev 4: 535-542.
  15. Hageman G, Oetelaar A, Welle I, Beurskens-Comuth P, Kleinjans J. 1995. Influence of smoking behavior in relation to plasma retinol and ${\alpha}-tocopherol$ on sister chromatid exchanges in human peripheral blood lymphocytes. Caner Epidemiol Biomarkers Prev 4: 289-293.
  16. Elmadfa I, Park E. 1999. Impact of diets with corn oil or olive/sunflower oils on DNA damage in healthy young men. Eur J Nutr 38: 286-292. https://doi.org/10.1007/s003940050079
  17. Park E, Wagenbichler P, Elmadfa I. 1999. Effects of multivitamin/mineral supplementation, at nutritional doses, on plasma antioxidant status and DNA damage estimated by sister chromatid exchanges in lymphocytes in pregnant women. Int J Vitam Nutr Res 69: 396-402. https://doi.org/10.1024/0300-9831.69.6.396
  18. Van Poppel G, Kok FJ, Duijzing P, Vogel N. 1992. No influence of beta-carotene on smoking-induced DNA damage as reflected by sister chromatid exchanges. Int J Cancer 51: 355-358. https://doi.org/10.1002/ijc.2910510304
  19. Shim JS, Lee HK, Kim YH, Roh JK, Anderson D. 1989. Sister-chromatid exchanges in 52 Korean women living in the vicinity of an industrial complex. Mutation Res 224: 511-515. https://doi.org/10.1016/0165-1218(89)90078-5
  20. Cho SS, Kang MH. 1993. The variations of the SCE frequency of human lymphocytes by smoking habits and dietary factors in college students. Korean J Nutrition 26: 313-324.
  21. Kang MH. 1994. Influence of dietary factors of smokers on smoking-induced DNA damage as reflected by sister chromatid exchanges (SCE). Korean J Nutrition 27: 740-751.
  22. Kang MH, Lim SS. 1994. The effect of ginseng intake on the frequency of sister chromatid exchanges of human lymphocyte of adult smokers. Korean J Nutrition 27: 253-262.
  23. Lee IP, Kim YH, Kang MH, Roberts C, Shim JS, Roh JK. 1997. Chemopreventive effect of green tea (Camellia sinensis) against cigarette smoke-induced mutations (SCE) in humans. J Cell Biochem Suppl 27: 68-75
  24. Carrano AV, Natarajan AT. 1988. Consideration for population monitoring using cytogenetic techniques. Mutation Res 204: 379-406. https://doi.org/10.1016/0165-1218(88)90036-5
  25. Soper KA, Stolley PD, Gallowy SM, Smith JG, Nichols WW, Wolman SR. 1984. Sister chromatid exchange (SCE) report on control subjects in a study of occupationally exposed workers. Mutation Res 129: 77-88. https://doi.org/10.1016/0027-5107(84)90126-X
  26. Guthrie HA, Scheer JC. 1981. Nutritional adequacy of selfselected diets that satisfy the four food groups guide. J Nutr Ed 13: 46.
  27. Lee JM, Kang MH, Lee MS, Park OJ. 1988. Evaluation of the nutritional status of Korean women in Taejon poverty area. Annual Report for the United Board for Christian higher Education in Asia.
  28. Simko MS, Cowell C, Gilbride JA. 1995. Nutrition Assessment: A Comprehensive Guide for Planning Intervention. 2nd ed. An Aspen Publication, Rockville, Maryland. p 130-134.
  29. Perry P, Wolff S. 1974. New Giemsa method for the differential staining of sister chromatids. Nature (London) 258: 121-125. https://doi.org/10.1038/258121a0
  30. Welch RW, Turley E, Sweetman SF, Kennedy G, Collins AR, Dunne A, Livingstone MBE, Mckenna PG, McKelvey-Martin VJ, Strain JJ. 1999. Dietary antioxidant supplementation and DNA damage in smokers and nonsmokers. Nutr and Cancer 34: 167-172. https://doi.org/10.1207/S15327914NC3402_7
  31. Duthie SJ, Ma A, Ross MA, Collins AR. 1996. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 56: 1291-1295.
  32. Krebs-Smith SM, Smiciklae-Wright H, Guthrie HA, Krebs-Smith J. 1987. The effects of variety in food choices on dietary quality. JADA 87: 897-903.
  33. Smith PG, Jick H. 1978. Cancers among users of preparations containing vitamin A. Cancer 42: 808-811. https://doi.org/10.1002/1097-0142(197808)42:2<808::AID-CNCR2820420255>3.0.CO;2-V
  34. Newberne PM, Rogers AE. 1973. Rat colon carcinomas associated with aflataxin and masginal vitamin A. J Natl Cancer Inst 50: 439-448.
  35. Smith D, MacGregor J, Hiatt R, Hooper N, Wehr C, Peters B, Goldman L, Yuan L, Smith P, Becker C. 1990. Micronucleated erythrocytes as an index of cytogenetic damage in humans: Demographic and dietary factors associated with micronucleated erythrocytes in splenectomized subjects. Cancer Res 50: 5049-5054.
  36. Wang Y, Ichiba M, Oishi H, Lyadomi M, Shono N, Tomokuni K. 1997. Relationship between plasma concentrations of ${\beta}-carotene$ and ${\alpha}-tocopherol$ and life-style factors and levels of DNA adducts in lymphocytes. Nutr Cancer 27: 69-73. https://doi.org/10.1080/01635589709514504
  37. Wulf HC, Kromann, Kousgaard N, Hansen JC, Niebuhr E, Alboge K. 1986. Sister chromatid exchage (SCE) in Greenland Eskimos. Dose-response relationship between SCE and seal diet, smoking, and blood cadmium and mercury concentrations. Sci of Total Environment 48: 81-94. https://doi.org/10.1016/0048-9697(86)90155-5
  38. Ames BN. 1983. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221: 1256-1264. https://doi.org/10.1126/science.6351251
  39. Boyle SP, Dobson VL, Duthie SJ, Kyle JAM, Collins AR. 2000. Absorption and DNA protective effects of flavonoids glycosides from an onion meal. Eur J Nutr 39: 213-223. https://doi.org/10.1007/s003940070014
  40. Block G, Patterson B, Subar A. 1992. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18: 1-29. https://doi.org/10.1080/01635589209514201
  41. Reddy BS. 1992. Dietary fat and colon cancer: animal model studies. Lipids 27: 803-813.
  42. Hopkin JM, Evans HJ. 1980. Cigarette-smoke induce DNA damage and lung cancer risks. Nature (London) 283: 388-390. https://doi.org/10.1038/283388a0
  43. Barale R, Sozzi G, Toniolo P, Borghi O, Reali D, Loprieno N, Della Porta G. 1985. Sister chromatid exchanges in lymphocytes and mutagenicity in urine of nurses handling cytostatic drugs. Mutation Res 157: 234-240.
  44. Aeschbacher HU, Meier H, Jaccaud E. 1986. The effect of caffeine in the in vivo SCE and micronules mutagenicity tests. Mutation Res 174: 53-58. https://doi.org/10.1016/0165-7992(86)90076-X
  45. Zeitlin BR. 1972. Letter to the Editor: Coffee and bladder cancer. Lancet 1: 1066.
  46. Oguni I, Nasu K, Kanaya S, Yamamoto S, Shimizu M, Nomura T. 1985. Epidemiological and experimental studies on the antitumor activity of fresh green tea leaf. Proc Annual Meeting Agricultural Chemical Soe Japan. p 153.
  47. Graham S, Dayal H, Swanson M, Mittelman A, Wilkinson G. 1978. Diet in the epidemiology of cancer of the colon and rectum. J Natl Cancer Inst 51: 709-714.
  48. Hoeft H, Obe G. 1983. SCE-inducing congeners in alcoholic beverages. Mutation Res 121: 247-251. https://doi.org/10.1016/0165-7992(83)90210-5
  49. Won TW, Lee SW, Kim WK. 1995. Effect on SCE frequency by DNA hypomethylation in cultured human lymphocytes. Korean J Genetics 17: 133-140.