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양파김치 메탄올추출물의 항암 및 면역활성

Anticancer and Immuno - Activity of Onion Kimchi Methanol Extract

  • 박경욱 (순천대학교 식품영양학과) ;
  • 김재용 (순천대학교 기초과학연구소) ;
  • 조영숙 (순천대학교 식품영양학과) ;
  • 이성태 (순천대학교 생물학과) ;
  • 정창호 (경상대학교 응용생명과학부) ;
  • 강갑석 (부산정보대학 레저산업개발) ;
  • 서권일 (순천대학교 식품영양학과)
  • Park, Kyung-Uk (Dept. of Food and Nutrition, Sunchon National University) ;
  • Kim, Jae-Yong (Research Institute of Basic Science, Sunchon National University) ;
  • Cho, Young-Sook (Dept. of Food and Nutrition, Sunchon National University) ;
  • Lee, Sung-Tae (Dept. to Biology, Sunchon National University) ;
  • Jeong, Chang-Ho (Dept. of Applied Life Sciences, Graduate School, Gyeongsang National University) ;
  • Kang, Kap-Suk (Group Dept. of Leisure Industry, Pusan Information and Technology College) ;
  • Seo, Kwon-Il (Dept. of Food and Nutrition, Sunchon National University)
  • 발행 : 2004.11.01

초록

양파 및 양파김치에 대한 항암 및 면역활성을 조사한 결과는 다음과 같다. 양파 및 양파김치 메탄올 추출물은 aflatoxin $B_1$로 돌연변이를 유도한 Salmonella typhimurium에 대하여 농도 의존적으로 항돌연변이 효과가 큰 것으로 나타났으며, 양파김치 첨가군이 양파의 첨가군보다 그 효과가 더욱 크게 나타났다. 양파 및 양파김치 메탄올 추출물은 A549 및 MCF-7 암세포주에 처리한 결과 추출물을 처리하지 않은 대조구에 비하여 1,000 ${\mu}$g/mL 농도에서 모두 20% 이상 그 성장을 억제하였다. 양파김치 메탄올 추출물은 농도에 비례하여 비장세포의 증식을 유도하였고, 양파 추출물보다 더 높은 증식을 유도하였다. 양파 및 양파김치 메탄올 추출물을 처리한 대식세포주에서 NO의 생성이 농도 의존적으로 증가하였으며, 역시 양파김치 추출물이 양파 추출물보다 더 많은 NO을 생성량을 유도하였다.

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피인용 문헌

  1. Effects of Onion Kimchi Extract Supplementation on Blood Glucose and Serum Lipid Contents in Streptozotocin-induced Diabetic Rats vol.37, pp.4, 2008, https://doi.org/10.3746/jkfn.2008.37.4.445
  2. Health benefits of lactic acid bacteria isolated from kimchi, with respect to immunomodulatory effects vol.24, pp.3, 2015, https://doi.org/10.1007/s10068-015-0102-3
  3. Relationships among Recognition, Preference, and Purchasing Characteristics for Local Agricultural Products and Festival Satisfaction of Changnyeong Area- Compared by the Gender, Age, and Purchase Experience - vol.29, pp.6, 2014, https://doi.org/10.7318/KJFC/2014.29.6.528
  4. Total Phenolic Content and DPPH Radical Scavenging Activity of Subcritical Water Extract of Onion, and Its Effect on Alcohol Dehydrogenase Activity vol.52, pp.1, 2018, https://doi.org/10.14397/jals.2018.52.1.71
  5. A survey of research papers on the health benefits of kimchi and kimchi lactic acid bacteria vol.51, pp.1, 2018, https://doi.org/10.4163/jnh.2018.51.1.1
  6. Improvement of cognitive function by Gochujang supplemented with tomato paste in a mouse model pp.2092-6456, 2019, https://doi.org/10.1007/s10068-019-00565-0