양파김치 메탄올추출물의 항암 및 면역활성

Anticancer and Immuno - Activity of Onion Kimchi Methanol Extract

  • 박경욱 (순천대학교 식품영양학과) ;
  • 김재용 (순천대학교 기초과학연구소) ;
  • 조영숙 (순천대학교 식품영양학과) ;
  • 이성태 (순천대학교 생물학과) ;
  • 정창호 (경상대학교 응용생명과학부) ;
  • 강갑석 (부산정보대학 레저산업개발) ;
  • 서권일 (순천대학교 식품영양학과)
  • Park, Kyung-Uk (Dept. of Food and Nutrition, Sunchon National University) ;
  • Kim, Jae-Yong (Research Institute of Basic Science, Sunchon National University) ;
  • Cho, Young-Sook (Dept. of Food and Nutrition, Sunchon National University) ;
  • Lee, Sung-Tae (Dept. to Biology, Sunchon National University) ;
  • Jeong, Chang-Ho (Dept. of Applied Life Sciences, Graduate School, Gyeongsang National University) ;
  • Kang, Kap-Suk (Group Dept. of Leisure Industry, Pusan Information and Technology College) ;
  • Seo, Kwon-Il (Dept. of Food and Nutrition, Sunchon National University)
  • 발행 : 2004.11.01


양파 및 양파김치에 대한 항암 및 면역활성을 조사한 결과는 다음과 같다. 양파 및 양파김치 메탄올 추출물은 aflatoxin $B_1$로 돌연변이를 유도한 Salmonella typhimurium에 대하여 농도 의존적으로 항돌연변이 효과가 큰 것으로 나타났으며, 양파김치 첨가군이 양파의 첨가군보다 그 효과가 더욱 크게 나타났다. 양파 및 양파김치 메탄올 추출물은 A549 및 MCF-7 암세포주에 처리한 결과 추출물을 처리하지 않은 대조구에 비하여 1,000 ${\mu}$g/mL 농도에서 모두 20% 이상 그 성장을 억제하였다. 양파김치 메탄올 추출물은 농도에 비례하여 비장세포의 증식을 유도하였고, 양파 추출물보다 더 높은 증식을 유도하였다. 양파 및 양파김치 메탄올 추출물을 처리한 대식세포주에서 NO의 생성이 농도 의존적으로 증가하였으며, 역시 양파김치 추출물이 양파 추출물보다 더 많은 NO을 생성량을 유도하였다.


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  2. Health benefits of lactic acid bacteria isolated from kimchi, with respect to immunomodulatory effects vol.24, pp.3, 2015,
  3. Relationships among Recognition, Preference, and Purchasing Characteristics for Local Agricultural Products and Festival Satisfaction of Changnyeong Area- Compared by the Gender, Age, and Purchase Experience - vol.29, pp.6, 2014,
  4. Total Phenolic Content and DPPH Radical Scavenging Activity of Subcritical Water Extract of Onion, and Its Effect on Alcohol Dehydrogenase Activity vol.52, pp.1, 2018,
  5. A survey of research papers on the health benefits of kimchi and kimchi lactic acid bacteria vol.51, pp.1, 2018,
  6. Improvement of cognitive function by Gochujang supplemented with tomato paste in a mouse model pp.2092-6456, 2019,