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Effects of Aralia elata, Acanthopanacis cortex and Ulmus davidiana Water Extracts on Plasma Biomarkers in Streptozotocin - Induced Diabetic Rats

두릅, 오가피 및 느릅 열수추출물이 Streptozotocin 투여 흰쥐의 혈장바이오마커에 미치는 영향

  • Shin, Kyong-Hee (Dept. of Food and Nutrition, Yeungnam University) ;
  • Cho, Soo-Yeul (Dept. of Food and Nutrition, Yeungnam University) ;
  • Lee, Mi-Kyung (Food and Bio-Industry Research Institute, Kyongbuk National University) ;
  • Lee, Jeong-Sook (Dept. of Food and Nutrition, Kosin University) ;
  • Kim, Myung-Joo (Dept. of Food Science and Nutrition, Daegu Polytechnic College)
  • 신경희 (영남대학교 식품영양학과) ;
  • 조수열 (영남대학교 식품영양학과) ;
  • 이미경 (경북대학교 식품생물산업연구소) ;
  • 이정숙 (고신대학교 식품영양학과) ;
  • 김명주 (대구산업정보대학 식품영양과)
  • Published : 2004.11.01

Abstract

This study was conducted to investigate the effects of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts on plasma glucose and biomarkers in the streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into normal and diabetic groups. The diabetic groups subdivided into the control group (DM), Aralia elata (DM-AE), Acanthopanacis cortex (DM-AC) and Ulmus davidiana (DM-UD). The extracts were supplemented in diet base on 11.42 g of raw materials/㎏ diet for 7 weeks. The diabetes was induced by injecting STZ (55 ㎎/㎏ B.W., i.p.) once 2 weeks before sacrifying. Plasma glucose level was significantly higher in the DM group than in the normal group, whereas insulin and C-peptide concentrations were significantly lowered in the DM groups compared to the normal group. These parameters were normalized in the DM-AE, DM-AC and DM-UD supplemented groups. Plasma albumin content was significantly lowered in the DM group compared to the normal group, yet it was significantly higher in the DM-AE group than in the DM group. Bilirubin and creatinine contents were elevated in the DM group, while the supplementation of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts ameliorate the change of these contents in STZ-induced diabetic rats. Plasma AST, ALT, ALP and LDH activities were significantly higher in the DM group than in the normal groups. The supplementation of Araliaceae family water extracts significantly lowered these parameters compared to the DM group. Accordingly, these results indicate that Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts would seem to improve the glucose and biomarker in STZ-induced diabetic rats.

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