DOI QR코드

DOI QR Code

Effects of Cereal and Red Ginseng Flour on Blood Glucose and Lipid Level in Streptozotocin - Induced Diabetic Rats

곡물류와 홍삼분말 급여가 당뇨성 흰쥐의 혈당 및 지질대사에 미치는 영향

  • Shon, Mi-Yae (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Choi, Sun-Young (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Cho, Hyun-So (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Sung, Nak-Ju (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University)
  • 손미예 (경상대학교 식품영양학과. 농업생명과학연구소) ;
  • 최선영 (경상대학교 식품영양학과. 농업생명과학연구소) ;
  • 조현소 (경상대학교 식품영양학과. 농업생명과학연구소) ;
  • 성낙주 (경상대학교 식품영양학과. 농업생명과학연구소)
  • Published : 2004.11.01

Abstract

This study was conducted to examine the effects of feeding diets containing bioorganic power (BP) flour, wheat flour and rice flour on blood glucose and lipid level in streptozotocin-induced diabetic rats. BP flour was composed with the mixture of defatted flour (16 g soybean, 12 g wheat, 8 g barley), 2 g red ginseng and 2 g whole wheat flour per 100 g diet. Experimental groups were divided into non-diabetic normal and 4 diabetic groups containing control, 40% BP, 41.6% wheat and 41.6% rice flours with basal diet. BP group was significantly increased body weight gain and decreased plasma glucose compared with the diabetic control, wheat and rice flour groups (p<0.05). Food efficiency ratio of diabetic rats were significantly lower than that of the normal rats. The concentrations of total cholesterol and triglyceride in plasma and atherogenic index were significantly decreased in BP, wheat and rice diabetic groups than diabetic control (p<0.05). The concentration of total cholesterol and triglyceride in liver was significantly lower in BP group as compared with the diabetic control, wheat and rice flour groups (p<0.05). In conclusion, the results indicated that BP flour feeding improved plasma glucose level, total cholesterol and triglyceride in diabetic rats.

References

  1. Wolff SP, Dean RT. 1987. Glucose autooxidation and protein modification: the potential role of autooxidative glycosylation in diabetes. Biochemical Journal 245: 243-246 https://doi.org/10.1042/bj2450243
  2. Defronzo RA. 1981. The effect of insulin on renal sodium metabolism. Diabetologia 21: 165-171
  3. Steiner G, Haynes F, Yoshino G. 1984. Hyperinsulinemia and in vivo very low density lipoprotein triglyceride kinetics. Am J Physio 246: 187-192
  4. Young IR, Stout RW. 1987. Effects of insulin and glucose on the cells of the arterial wall: Interaction of insulin with dibutyryl cyclic AMP and low density lipoprotein in arterial cells. Diabetes Metab 13: 301-306
  5. Korea National Statistical Office. 2002. The cause of death statistics 2001. Annual Report on the Cause of Death Statistics p 21
  6. Ivorra MD, Paya M, Villar A. 1988. Hypoglycemic and insulin release effects of tormentic acid: a new hypoglycemic natural product. Planta Med 54: 282-285 https://doi.org/10.1055/s-2006-962433
  7. Ko JB. 1996. Effects of raw soy flour (yellow and black) on serum glucose and lipid concentration in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 27: 313-318
  8. Rho MH, Choi MA, Koh JB. 1998. Effects of raw soy flour (yellow and black) on serum protein concentrations and enzyme activity in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 27: 724-730
  9. Choi MJ. 1997. Comparison of dietary casein or soy protein effect on plasma glucose, lipids and hormone concentrations in the streptozotocin-induced diabetic rats. J Research Institute for Life Sciences (Keimyung University) 23: 285-295
  10. Choi MJ, Han YJ. 1994. Effects of the soy protein level on plasma glucose, lipids, and hormones in streptozotocin-diabetic rats. Korean J Nutrition 27: 883-891
  11. Kim MH, Kim HY, Kim WK, Kim JY, Kim SH. 2001. Effects of soyoligosaccharide on blood glucose and lipid metabolism in streptozotocin-induced diabetic rats. Korean J Nutrition 34: 3-13
  12. Jha HC. 1985. Inhibition of in vitro microsomal lipid peroxidation by isoflavonoids. Biochem Pharmacol 34: 1367-1369 https://doi.org/10.1016/0006-2952(85)90672-0
  13. Bates SH, Jones RB, Bailey CJ. 2000. Insulin-like effect of pinitol. Br J Pharmacol 130: 1944-1948 https://doi.org/10.1038/sj.bjp.0703523
  14. Fleming A, Gunn R, Longo R, Sleevi M, Gregory J, Rogol A. 2001. Evaluation of D-chiro-inositol (Ins-1) in combination with sulfonylureas on glycemic control and lipids in subjects with type 2 diabetes mellitus. 61th Scientific Session of American Diabetes Association. Abstract No. 448-P, June 22-26, Philadelphia, Pennsylvania
  15. Kim JI, Kang MJ, Bac SY. 2003. Hypoglycemic effect of the methanol extract of soybean sprout in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 32: 921-925
  16. Lee YT. 2003. Preparation and hypoglycemic effect of reconstituted grain added with selected medicinal herb extract. Korean J Food Sci Technol 35: 527-531
  17. Lee IS, Lee SO, Lee IZ. 2003. Effects of tissue cultured ginseng on blood glucose and lipids in streptozotocin-induced diabetic rats. Korean J Food Sci Technol 35: 280-285
  18. Park KS, Ko SK, Chung SH. 2003. Comparisions of antidiabetic effect between Ginseng Radix Alba, Ginseng Radix Rubra and Panax Quinquefoli Radix in MLD STZ-induced diabetic rats. J Ginseng Res 27: 56-61 https://doi.org/10.5142/JGR.2003.27.2.056
  19. Kwak YS, Park JD, Yang JW. 2003. Present and its prospect of red ginseng efficiency research. Food Industry and Nutrition 8: 30-37
  20. Kim HS, Seong YH, Yang JW, Jeon BS, Park UY, Park WK, Oh KW, Choi KJ. 1997. Hypoglycemic effects of extract mixture of red ginseng and steamed Rehmaniae radix on streptozotocin-induced daibetic rats. Korean J Ginseng Sci 21: 169-173
  21. Kimura M, Wakai I, Kikuchi T. 1981. Hypoglycemic components from Ginseng radix and the action insulin release. Proc Symp Wakan Yaku 14: 125-131
  22. Yamamoto M. 1984. Long term ginseng effects on hyperlipidemia in man with further study of its action on atherogenesis and fatty lover in rats. 4th Int'l Ginseng Symp. Ginseng Research Institute, Seoul, Korea. p 13-20
  23. Lee JS, Son HS, Maeng YS, Chang YK, Ju JS. 1994. Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats. Korean J Nutrition 27: 819-827
  24. Newman RK, Lewis SE, Newman CW, Boik RJ, Ramage RT. 1989. Hypocholesterolemic effect of barley foods on healthy men. Nutr Rep Int 39: 749-757
  25. Kim SR, Seog HM, Choi HD, Park YK. 2002. Cholesterol- lowering effects in rat liver fed barley and $\beta$-glucan-enriched barley fraction with cholesterol. Korean J Food Sci Technol 34: 319-324
  26. Koh JB, Choi MA. 1999. Effect of tea fungus/kombucha beverage on lipid metabolism in streptozotocin-induced diabetic male rats. J Korean Soc Food Sci Nutr 28: 613-618
  27. Lim SJ, Han HK, Ko JH. 2003. Effects of edible and medicinal plants intake on blood glucose, glycogen and protein levels in streptozotocin induced diabetic rats. Korean Nutr Soc 36: 981-989
  28. Park MS, Kudchodkar BJ, Liepa GU. 1987. Effect of dietary animal and plants proteins on the cholesterol metabolism in immature and mature rats. J Nutr 117: 30-37
  29. American Institute Nutrition. 1977. Report of the American institute nutrition ad hoc committee on standards for nutritional studies. J Nutr 107: 1340-1347
  30. Folch J, Lees M, Stanley GH. 1956. A simple·method for the isolation and purification of total lipid from animal tissues. J Biol Chem 223: 498-500
  31. Sale FO, Marchesini S, Fishman PH, Berra B. 1984. A sensitive enzymatic assay for determination of cholesterol in lipid extracts. Anal Biochem 142: 347-352 https://doi.org/10.1016/0003-2697(84)90475-5
  32. Koh JB, Kim JY, Rho MH. 1996. Effects of raw soy flour yellow and black diet on serum protein concentration and enzyme activity in streptozotocin-diabetic rats. J Nat Sci Pusan Woman Univ 2: 1-11
  33. Domingo JL, Gimez M, Llobet JM, Gorbella J, Keen CL. 1991. Oral vanadium administration to streptozotocin-diabetic rats has marked negative side effects which are in dependent of vanadium used. Toxicology 66: 279-287 https://doi.org/10.1016/0300-483X(91)90199-B
  34. Ko JB, Kim JY, Rho MH. 1996. Effects of raw soy flour and magnesium on serum protein concentration and enzyme in streptozotocin-diabetic rats. J Nat Sci Pusan Womem's Univ 2: 1-11

Cited by

  1. Ameliorative Effect of Black Ginseng on Diabetic Complications in C57BLKS/J-db/db Mice vol.25, pp.1, 2012, https://doi.org/10.9799/ksfan.2012.25.1.099
  2. Effects of Dietary Inclusion of Red Ginseng Byproduct on Growth, Body Composition, Serum Chemistry, and Lysozyme Activity in Juvenile Olive Flounder (Paralichthys olivaceus) vol.13, pp.4, 2010, https://doi.org/10.5657/fas.2010.13.4.300
  3. Antihyperglycemic of Gleditschiae Spina Extracts in Streptozotocin-Nicotinamide Induced Type 2 Diabetic Rats vol.40, pp.2, 2011, https://doi.org/10.3746/jkfn.2011.40.2.321
  4. Effects of Dietary Supplementation of Red Ginseng Mare and Korean Mistletoe Powder on Performance and Meat Quality of Broiler Chicken vol.41, pp.3, 2014, https://doi.org/10.5536/KJPS.2014.41.3.197
  5. Anti-Diabetic Effect of Red Ginseng-Chungkukjang with Green Laver or Sea Tangle vol.15, pp.3, 2010, https://doi.org/10.3746/jfn.2010.15.3.176
  6. A Study on the Saponin Contents and Antioxidant Activity of the Ginseng and Extruded Ginseng by Using Different Solvents for Extraction vol.24, pp.4, 2011, https://doi.org/10.9799/ksfan.2011.24.4.528