DOI QR코드

DOI QR Code

Morphological Changes in the Skin of Hairless Mouse Fed Various Kimchi Diet

김치종류별 식이가 Hairless Mouse 피부의 형태학적 변화에 미치는 영향

  • Ryu, Bog-Mi (Dept. of Food Science and Nutrition and Kimchi Research institute, Pusan National University) ;
  • Ryu, Seung-Hee (Biohealth Products Research Center, Food Science Institute and School of Food and Life Science,Inje University) ;
  • Yang, Young-Churl (Dept. of Anatomy, College of Medicine, Inje University) ;
  • Lee, Yu-Soon (Dept. of Cosmetic Engineering, Kyongbuk College of Science) ;
  • Jeon, Young-Soo (Dept. of Food Science and Nutrition and Kimchi Research institute, Pusan National University) ;
  • Moon, Gap-Soon (Biohealth Products Research Center, Food Science Institute and School of Food and Life Science,Inje University)
  • 류복미 (부산대학교 식품영양학과 및 김치연구소) ;
  • 류승희 (인제대학교 바이오헬스 소재 연구센터, 식품과학연구소 및 식품생명과학부) ;
  • 양영철 (인제대학교 의과대학 해부학 교실) ;
  • 이유순 (경북과학대학 향장공업과) ;
  • 전영수 (부산대학교 식품영양학과 및 김치연구소) ;
  • 문갑순 (인제대학교 바이오헬스 소재 연구센터, 식품과학연구소 및 식품생명과학부)
  • Published : 2004.11.01

Abstract

Skin is the most frequently exposed tissues to oxidative stress from exogenous and endogenous sources. Dietary antioxidants, which suppress oxidative stress including reactive oxygen metabolites, play an important role in protecting skin from deleterious reactive oxygen species. Kimchi containing lots of antioxidative compounds shows anti-aging effect on skin. Therefore the morphologic changes on the skin of hairless mice fed diets containing Korean cabbage, mustard leaf, and buchu kimchi for 16 weeks were determined. Although epidermal thickness was decreased with age, kimchi prevented this thinning of epidermis compared to control group. In kimchi groups, the staining area of cytokeratin was smaller and stratum corneum was thinner than control group. It suggests that various kinds of kimchi diets prevent the increase of keratinization in epidermis with aging. Type Ⅳ collagen, a major structural protein of basement membrane supporting matrices, existed greater amount in kimchi groups than control group, especially in mustard leaf kimchi group. Rough endoplasmic reticulum (RER) of fibroblast was well developed in dermis of Korean cabbage and mustard leaf kimchi groups, which means collagen synthesis at dermis increased in those kimchi groups. This morphological changes of skin suggest that kimchi consumption can retard skin aging due to the presence of antioxidant and anti-aging compounds, especially some components of mustard leaf kimchi may largely affect on the skin rejuvenescence.

References

  1. Cheigh HS. 1995. Biochemical characteristics of kimchi. J East Asian Soc Dietary Life 5: 89-101
  2. Lee YO, Park KY, Cheigh HS. 1996. Antioxidative effect of kimchi with various fermentation period on the lipid oxidation of cooked ground meat. J Korean Soc Food Nutr 25: 261-266
  3. Park PS, Lee MY. 1992. The effects of onion and garlic on copper-phenanthroline complex induced DNA degradation. J Korean Soc Food Nutr 21: 367-371
  4. Cho YS, Song JC, Yang CB. 1999. Protective effects of ginger, garlic, and onion against radical reaction induced by carbon tetrachloride in rats. Korean J Food Sci Technol 31: 1084-1089
  5. Kang JH, Ahn BW, Lee DH, Byun HS, Kim SB, Park YH. 1988. Inhibitory effects of ginger and garlic extracts on the DNA damage. Korean J Food Sci Technol 20: 287-292
  6. Kwon MJ, Song YO, Song YS. 1997. Effects of kimchi on tissue and fecal lipid composition and apolipoprotein and thyroxine levels in rats. J Korean Soc Food Sci Nutr 26: 507-513
  7. Kim JY, Lee YS. 1997. The effects of kimchi intake on lipid contents of body and mitogen response of spleen lymphocytes in rats. J Korean Soc Food Sci 26: 1200-1207
  8. Kim MJ, Kwon MJ, Song YO, Lee EK, Youn HJ, Song YS. 1997. The Effects of kimchi on hematological and immunological parameters in vivo and in vitro. J Korean Soc Food Sci 26: 1208-1214
  9. Kim JH, Kwon MJ, Lee SY, Ryu JD, Moon GS, Cheigh HS, Song YS. 2002. The effect of kimchi intake on production of free radicals and anti-oxidative enzyme activities in the liver of SAM. J Korean Soc Food Sci Nutr 31: 109-116 https://doi.org/10.3746/jkfn.2002.31.1.109
  10. Kim JH, Ryu JD, Lee HG, Park JH, Moon GS, Cheigh HS, Song YS. 2002. The effect of kimchi intake on production of free radicals and anti-oxidative enzyme activities in the brain of SAM. J Korean Soc Food Sci Nutr 31: 117-123 https://doi.org/10.3746/jkfn.2002.31.1.117
  11. Ryu SH, Jeon YS, Kwon MJ, Moon JW, Lee YS, Moon GS. 1997. Effect of kimchi extracts to reactive oxygen species in skin cell cytotoxicity. J Korean Soc Food Sci Nutr 26: 814-821
  12. Ryu SH, Jeon YS, Moon JW, Lee YS, Moon GS. 1997. Effect of kimchi ingredients to reactive oxygen species in skin cell cytotoxicity. J Korean Soc Food Sci Nutr 26: 998-1005
  13. Ryu BM, Ryu SH, Lee YS, Jeon YS, Moon GS. 2004. Effect of different kimchi diets onoxidation and photooxidation in hairless mouse. J Korean Soc Food Sci Nutr 33: 291-298 https://doi.org/10.3746/jkfn.2004.33.2.291
  14. Korean Dermatological Association. 1994. Textbook of dermatology. 3rd ed. Yemoungak, Seoul. p 1-25
  15. Han KH, Cho KH, Noh DY, Eun HC, Youn JI. 1998. Histological changes in the skin with innate aging. Korean J Dermatol 36: 971-980
  16. Choi JY, Yoon KS, Cho YH, Kim NI. 1996. The effect of UVB irradiation and sunscreen agents on photoaging of hairless albino mouse skin. Kor J Dermatol 34: 289-299
  17. Dattner AM. 1999. Nutritional Dermatology. Clinics in Dermatol 17: 57-64 https://doi.org/10.1016/S0738-081X(98)00051-0
  18. Biesalski HK, Obermuelle-Jevic UC. 2001. UV light, beta- carotene and human skin-beneficial and potentially harmful effects. Arch Biochem Biophys 389: 1-6 https://doi.org/10.1006/abbi.2001.2313
  19. Kefalides NA, Alper R, Clarke C. 1979. Biochemistry and metabolism of basement membranes. Int Rev Cytol 61: 167-228 https://doi.org/10.1016/S0074-7696(08)61998-1
  20. Vazquez F, Palacios S, Aleman N, Guerrero F. 1996. Changes of the basement membrane and type Ⅳ collagen in human skin during aging. Maturitas 25: 209-215 https://doi.org/10.1016/S0378-5122(96)01066-3
  21. Chung JH, Seo JY, Choi HR, Lee MK, Youn CS, Rhie GE, Cho KH, Kim KH, Park KC, Eun HC. 2001. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 117: 1218-1224 https://doi.org/10.1046/j.0022-202x.2001.01544.x
  22. Jenkins G. 2002. Molecular mechanisms of skin ageing. Mechanisms of Ageing & Development 123: 801-810 https://doi.org/10.1016/S0047-6374(01)00425-0
  23. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE. 1995. A novel biomarker that the identifies senescent human cells in culture and ageing skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367 https://doi.org/10.1073/pnas.92.20.9363
  24. Dalle Cabonare M, Pathak MA. 1994. Skin photosensitizing agents and the role of reactive oxygen species in photoageing. J Photochem Photobiol B 14: 105-124 https://doi.org/10.1016/1011-1344(92)85086-A
  25. Shapiro SS, Saliou C. 2001. Role of vitamins in skin care. Nutr 17: 839-844 https://doi.org/10.1016/S0899-9007(01)00660-8
  26. Svendsen L, Rattan SI, Clark BF. 1994. Testing garlic for possible anti-aging effects on long term growth charac-teristics, morphology and macromolecular synthesis of human fibroblasts in culture. J Ethanopharmacol 43: 125-133 https://doi.org/10.1016/0378-8741(94)90009-4
  27. Epstein JH. 1977. The pathological effects of light on the skin. In Free radicals in Biology. Pryor WA, ed. Academic Press, New York. Vol 3, p 219-249
  28. Tahara S, Matsuo M, Kaneko T. 2001. Age-related changes in oxidative damage to lipids and DNA in rat skin. Mechanisms of Ageing & Development 122: 415-426 https://doi.org/10.1016/S0047-6374(00)00257-8

Cited by

  1. A survey of research papers on the health benefits of kimchi and kimchi lactic acid bacteria vol.51, pp.1, 2018, https://doi.org/10.4163/jnh.2018.51.1.1