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Effect of a Herb Mixture (HIM-I) on the Protection of the Hematopoietic-Immune System and Self-renewal Tissues against Radiation Damage

면역조혈계 및 재생조직의 방사선 손상에 대한 생약복합물(HIM-I)의 방호 효과

  • Park, Hae-Ran (Radiation Food and Biotechnology Team, Korea Atomic Energy Research Institute) ;
  • Kim, Sung-Ho (College of Veterinal Medicine, Chonnam National University) ;
  • Yee, Sung-Tae (Dept. of Biology, Sunchon National University) ;
  • Byun, Myung-Woo (Radiation Food and Biotechnology Team, Korea Atomic Energy Research Institute) ;
  • Jo, Sung-Kee (Radiation Food and Biotechnology Team, Korea Atomic Energy Research Institute)
  • 박혜란 (한국원자력연구소 방사선식품생명공학팀) ;
  • 김성호 (전남대학교 수의과대학) ;
  • 이성태 (순천대학교 생물학과) ;
  • 변명우 (한국원자력연구소 방사선식품생명공학팀) ;
  • 조성기 (한국원자력연구소 방사선식품생명공학팀)
  • Published : 2005.06.01

Abstract

In previous studies, we evaluated the effect of the 6 energy-tonic or blood-building prescriptions of traditional oriental medicine, and observed that Si-Wu-Tang and Bu-Zhong-Yi-Qi-Tang showed high activity in the protection of the gastrointestinal and hematopoietic organs in irradiated mice. But any of these prescriptions did not show a high activity in the activation of the immune cells. We performed this study to design an herb mixture which protects the self-renewal tissues and also promotes recovery of the immune system against radiation damage. In order to meet all the requirements, we designed a new mixture of 3 edible herbs listed in Korean Food Code. The mixture of Angelim gigas radix, Cnidium officinale rhizoma and Paeonia japonica radix was decocted with hot water, and the activities of the water extract (HIM-I) were evaluated. HIM-1 stimulated the immune cells in a much higher extent than the traditional prescriptions, and promoted dramatically the growth of bone marrow stem cells in vitro. Also, HIM-1 protected digestive and hematopoietic organs against radiation as effectively as the 2 prescriptions, Si-Wu-Tang and Bu-Zhong-Yi-Qi-Tang. On the other hand, it showed high in vitro antioxidative activity that might be considered as a mechanism of the protective effects against radiation. Although the detailed mechanisms of those effects remain to be elucidated, these results indicated that HIM-I might be a useful agent for protection and recovery of body from various risk factor as well as radiation, especially since it is a relatively nontoxic natural product.

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