Effects of Acorn (Quercus acutissima CARR.) Supplementation on the Level of Acetylcholine and Its Related Enzyme Activities in the Brain of Dementia Mouse Model

도토리 급여가 치매모델 마우스 뇌조직의 아세틸콜린 및 관련효소 활성에 미치는 영향

  • Lee, Sung-Hyeon (National Rural Resources Development Institute, NIAST, RDA) ;
  • Kim, Dae-Ik (National Rural Resources Development Institute, NIAST, RDA) ;
  • Cho, So-Yong (National Rural Resources Development Institute, NIAST, RDA) ;
  • Jung, Hyun-Jin (National Rural Resources Development Institute, NIAST, RDA) ;
  • Cho, Soo-Muk (National Rural Resources Development Institute, NIAST, RDA) ;
  • Park, Hong-Ju (National Rural Resources Development Institute, NIAST, RDA) ;
  • Lillehoj Hyun S. (Animal and Natural Resources institute, ARS- USDA)
  • 이성현 (농촌진흥청 농업과학기술원 농촌자원개발연구소) ;
  • 김대익 (농촌진흥청 농업과학기술원 농촌자원개발연구소) ;
  • 조소영 (농촌진흥청 농업과학기술원 농촌자원개발연구소) ;
  • 정현진 (농촌진흥청 농업과학기술원 농촌자원개발연구소) ;
  • 조수묵 (농촌진흥청 농업과학기술원 농촌자원개발연구소) ;
  • 박홍주 (농촌진흥청 농업과학기술원 농촌자원개발연구소) ;
  • Published : 2005.06.01


This study was designed to investigate the anti-dementia effects of acorn (Quercus acutissima CARR.) in brain of the mouse. Dementia model was induced by administration of scopolamin (30 mg/kg BW) Male ICR mouse $(30{\pm}2g\;BW)$ were fed basal diet (control group), and experimental diets (AP-5 and AP-10 groups) added $5\%\;and\;10\%$ of dried acorn powder to basal diet for 8 months. Acetylcholine content significantly increase in AP-5 and AP-10 groups ($4.2\%\;and\;11.3\%$, respectively) compared with control group. Acetylcholinesterase activities were significantly inhibited ($13.5\%\;and\;17.6\%$, respectively) in brain of AP-5 and AP-10 groups. Monoamine oxidase-B (MAO-B) activities were significantly inhibited ($10.0\%\;and\;12.7\%$, respectively) in brain of AP-S and AP-10 groups. These results suggest that acorn (Q. acutissima CARR.) may play an effective role in an attenuating various age-related changes such as dementia including learning and memory impairments in brain.


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