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Report on the changes of LD50 of Bee venom Herbal Acupuncture

봉약침의 LD50 변화 보고

  • Jang, Seong-Bong (Department of Acupuncture & Moxibution, College of Oriental Medicine, Sang-ji University) ;
  • Choi, Young-Kwon (Department of Acupuncture & Moxibution, College of Oriental Medicine, Sang-ji University) ;
  • Kwon, Ki-Rok (Department of Acupuncture & Moxibution, College of Oriental Medicine, Sang-ji University)
  • 장성봉 (상지대학교 한의과대학 침구학교실) ;
  • 최영권 (상지대학교 한의과대학 침구학교실) ;
  • 권기록 (상지대학교 한의과대학 침구학교실)
  • Published : 2005.02.28

Abstract

Objectives : This experiment was conducted to reevaluate $LD_{50}$ of Korean bee venom acupuncture as many changes have occurred over the years. Methods : ICR mice were used as the experiment animals and bee venom acupuncture was manufactured under the protocols of Korean Institute of herbal Acupuncture. Based on the previous reports, experiment was divided into pre and main sections. Results : 1. Presumed $LD_{50}$ value is at 5.25mg/kg 2. Deaths of experiment animals occurred within 48 hours. 3. Reduced toxicity of the bee venom acupuncture is likely to be the results of more refined manufacturing process and production. Conclusion : Comparing with the values of the previous results, toxicity of the bee venom acupuncture showed significant changes and more accurate findings on $LD_{50}$ value must be accomplished to lead further studies on the bee venom acupuncture.

References

  1. 김양강, 독성학, 동화기술, 서울, 15-18, 1994.
  2. 식품의약품안전본부, '의약품 독성시험기준' 제98-116호, 1988.
  3. 허인회 외, 독성학. 신일상사, 37, 1993.
  4. 고형균, 봉침독요법이 항염, 진통 및 해열에 미치는 효능에 관한 실험적 연구. 대한한의학회지 Vol. 13, No. 1, 290, 1992.
  5. 이종석 외, 봉독의 치사량에 관한 실험적 연구. 대한침구학회지, 10권. 1 호, 151-157, 1993.
  6. 이종석, 고형균, 김창환. 약침용봉독액의 급성독성에 관한 연구. 대한침구학회지, 11 : 1, 177-191, 1994.
  7. 김문호, 봉독요법과 봉침요법, 서울, 한국교육기획, 104-105, 1992.
  8. 대한약침학회. 약침요법 시술 지침서, 대한약침학회, 서울, 133-135, 1999
  9. 최대봉, 양봉협회보, 한국양봉협회, 1988. 12
  10. 강대인, 권기록. A report on the manufracturing process of Korean Herbal Acupuncture prepared with KGMP. 대한약침학회지, 4 : 1, 87-101, 2001. https://doi.org/10.3831/KPI.2001.4.1.087
  11. 이진선, 권기록, 최호영, HPLC를 이용한 봉약침의 주요 성분에 관한 연구. 대한침구학회지, 17: 4120-129, 2000.
  12. 이정수, 인체 생리학, 도서출판 정담, 46-49, 1994.
  13. 최승윤, 양봉 꿀벌과 벌통, 오성출판사, 350, 1987.

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