Potential Effect of Solvent Fractions of Taraxacum mongolicum H. on Protection of Gastric Mucosa

민들레(Taraxacum mongolicum H.) 추출분획물이 위장보호에 미치는 효능 평가

  • 한소희 ((주)알로에마임 중앙연구소) ;
  • 황정근 ((주)알로에마임 중앙연구소) ;
  • 박수남 (서울산업대학교 정밀화학과) ;
  • 이길홍 (서울산업대학교 정밀화학과) ;
  • 고강일 ((주)바이오랜드 생명공학연구소) ;
  • 김기수 ((주)바이오랜드 생명공학연구소) ;
  • 김기호 ((주)바이오랜드 생명공학연구소)
  • Published : 2005.02.28


Mongolian dandelion (Taraxacum mongolicum H.) extracted with solvents having different polarities were prepared to investigate protection activity of gastric mucosa. Ethanol extracts were successively reextracted with methylene chloride, and n-butanol. Concentrations of total flavonoids and luteolin in n-butanol extracts were 27.75 and 1.14%, respectively, much higher than those of other solvent extracts. Results of anti-microbial acitivity test against Helicobacter pylori and urease inhibition test revealed n-butanol extract exerted higher inhibition (13.16%) than other solvent extracts. Based on 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, n-butanol extract showed the highest efficiency of free radical-scavenger activity among the extracts ($SC_{50}\;47{\mu}g/mL$). Erythrocytic photohemolysis tests, for the protection of cell membrane showed that half-life of human erythrocytes was increased by the addition of n-butanol extract $({\tau}_{50}=172min;C=5.0{\mu}g/mL)$. These results indicate n-butanol extract of Mongolian dandelion may be useful as a adjuvant for gastric diseases.


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