Tissue Concentrations of Quercetin and Its Metabolite Isorhamnetin Following Oral Administration of Quercetin in Mice

Mouse에서의 quercetin 경구투여 후의 체내 농도 및 대사체 isorhamnetin의 농도변화

  • Park, Kwan-Ha (Department of Aquatic Life Medicine, Kunsan National University) ;
  • Choo, Jong-Jae (Department of Food Science & Nutrition, Kunsan National University) ;
  • Choi, Sun-Nam (Department of Food Science & Engineering, Kunsan National University)
  • 박관하 (군산대학교 해양과학대학 수산생명의학과) ;
  • 주종재 (군산대학교 식품영양학과) ;
  • 최선남 (군산대학교 식품공학과)
  • Published : 2005.02.28

Abstract

Absorption, metabolism, and tissue concentrations of quercetin were examined and compared in mice and rats after oral administration of quercetin at 50 or 100 mg/kg. Quercetin was absorbed quickly in mice and reached maximum plasma concentration in I hr post-administration, and declined sharply after 4 hr. Plasma concentration of isorhamnetin, a major metabolite, also increased sharply, indicating rapid metabolic conversion, but elevated level was maintained longer than that of quercetin. Quercetin and isorhamnetin were found predominantly in glucuronide/sulfate-conjugate forms in both mice and rats. Tissue concentrations of quercetin and isorhamnetin in mice and rats were in the order of liver>kidney>spleen>plasma both 1 and 6 hr postadministration. These results show that quercetin is absorbed in mice after oral feeding and quickly metabolized into isorhamnetin as demonstrated in humans and other animal species. The results also can be used to explain various pharmacological activities reported in mouse models.

Keywords

quercetin;isorhamnetin;mice;rat;HPLC

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