Antimicrobial, Antihypertensive and Anticancer Activities of Medicinal Herbs

생약재의 항균, 항고혈압 및 항암 활성

  • Published : 2005.04.30

Abstract

Antibacterial, antifungal, anticancer and angiotensin-converting enzyme (ACE) inhibitory activities of water and 70% ethanol extracts of 32 medicinal herbs species were investigated. Terminalia chebula extracts showed strong antibacterial activities. Ethanol extract of Cinnamomum cassia showed good antifungal activity. ACE inhibitory activities or P. corylifolia water extract and Fraction I of P. corylifolia water extract were 65.2 and 81.8%, respectively. Cytotoxicity of ethanol precipitate fraction obtained from water extract of Eugenia caryophyllata was highest.

Keywords

medicinal herb;antibacterial;antifungal effect;antihypertensive;anticancer

References

  1. King A, Young G. Characteristics and occurrence of phenolic phytochemicals. J. Am. Diet. Assoc. 99: 213-218 (1999) https://doi.org/10.1016/S0002-8223(99)00051-6
  2. Lee SH, Lim YS. Antimicrobial effects of Schizandra chinensis extract on pathogenic microorganism. J. Korean Soc. Food Sci. Nutr. 27: 239-243 (1998)
  3. Ikigai H, Nakae T, Hara Y, Shirnamura T. Bactericidal catechins damage the lipid bilayer. Biochim Biophys Acta. 1147: 132-136 (1993) https://doi.org/10.1016/0005-2736(93)90323-R
  4. Goun EA, Petrichenko VM, Solodnikov SU, Suhinina TV, Kline MA, Cunningham G, Nguyen C, Miles H. Anticancer and antithrombin activity of Russian plants. J. Ethnopharmacol. 81: 337-342 (2002) https://doi.org/10.1016/S0378-8741(02)00116-2
  5. Carmichael J, De Graff WG, Gazder AF, Minna JD, Mitchell JB. Evalution of a tetrazolium based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47: 943-946 (1987)
  6. Frazier WA, Bartles JR. Discoidin I-membrane interactions I. Discoidin I binds to two types of receptor on fixed Dictyostelium discoideum cells. Bioch. Biophys. Acta 687: 121-128 (1982) https://doi.org/10.1016/0005-2736(82)90537-5
  7. Do JR, Kang SN, Kim KJ, Jo JH, Lee SW. Antimicrobial and antioxidant activies and phenolic contents in the water extract of medicinal plants. Food Sci. Biotechnol. 13: 640-645 (2004)
  8. Chihara G, Hamuro J, Maeda Y, Arai Y, Fukuoka Y. Fructionation and purification of the polysaccharides with marked antitumor activity, especially Lentinarr, from Lentinusedodessing. Cancer Res. 30: 2276-2278 (1970)
  9. Lee BW, Shin DH. Screening of Natural Antimicrobial Plant Extract on Food Spoilage Microorganisms. Korean J. Food Sci. Technol. 23: 200-204 (1991)
  10. Chung CK, Park OK, Yoo IJ, Park KM, Choi CU. Antimicrobial activity of essential oils of curry spices. Korean J. Food Sci. Technol. 22: 716-719 (1990)
  11. Yang CS, Wang ZY, Tea and cancer, J. Natl. Cancer Inst. 85: 1038-1049 (1993) https://doi.org/10.1093/jnci/85.13.1038
  12. Sofos JN, Bcuchat LR, Davidson PM, Johnson EA. Naturally occurring antimicrobials in food. Regul. Toxicol. Pharmacol. 28: 71-72 (1998) https://doi.org/10.1006/rtph.1998.1246
  13. Ha YL, Michael WP. Naturally occuring novel auticarcinogenes: Conjugated dienoic derivaticcs of linoleic acid(CLA). J. Korean Soc. Food Nutr. 20: 401-407 (1991)
  14. Ayres HM, Payne DN, Furr JR, Russell AD. Use of Malthus-AT system to assess the efficacy of permeabilizing agents on the activity of antibacterial agents Pseudomonas aeruginosa. Lett. Appl. Microbiol. 26: 422-426 (1998) https://doi.org/10.1046/j.1472-765X.1998.00364.x
  15. Powell CB, Fung P, Jackson J, Dall'Era J, Lewkowicz D, Cohen I, Smith-McMune K. Aqueous extract of herba Scutellaria barbatae, a chinese herb used for ovarian cancer, induces apoptosis of ovarian cancer cell lines. Gynecol. Oncol. 91: 332-340
  16. Huang Y, Zhang A, Lau CW, Chen ZY. Vasorelaxant effects of purified green tea epicatechin derivatives in rat mesenteric artery. Life Sci. 63: 257-283 (1998)
  17. Park UY, Chang DS, Cho HR. Antimicrobial effect of lithospermi radix tLithospermum erythrorhizoni extract. J. Korean Soc. Food Nutr. 21: 97-100 (1992)
  18. Maruyama S, Miyoshi S, Tanaka H. Angiotensin I -converting enzyme inhibitors derived from ficus carica. Agric Biol. Chem. 53: 2763-2767 (1989) https://doi.org/10.1271/bbb1961.53.2763
  19. Cushman OW, Cheung HS. Spectrophotometric asaay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20: 1637-1648 (1971) https://doi.org/10.1016/0006-2952(71)90292-9
  20. Golovinsky EV, Maneva LS, Angelov I I, Veljanova KD, Sniker DJ, Stankevich EK. Antibacterial and antitumor activity of some derivatives of ureidosuccinic acid. Neoplasma. 23: 43-46 (1976)
  21. Suzuki T, Ishikawa N, Meguro H. Angiotensin I converting enzyme inhibitory activity in foods. Nippon Nogeiogaku Kaishi. 57: 1143-1146 (1983) https://doi.org/10.1271/nogeikagaku1924.57.1143
  22. Baratta MT, Dorman HJD, Deans SG, Figueiredo AC, Barroso JG, Ruberto G. Antimicrobial and antioxidant properties of some commercial essential oils. Flavour Fragr. J. 13: 235-244 (1998) https://doi.org/10.1002/(SICI)1099-1026(1998070)13:4<235::AID-FFJ733>3.0.CO;2-T
  23. Hong NO, Rho YS, Kim NJ, Kim JS. A Study on Efficacy of Ulmi Cortex. Korean J. Pharmacogn. 21: 217-222 (1990)
  24. Park UY, Chang DS, Cho HR. Antimicrobial effect of medicinal herb. J. Korean Soc. Food Nutr. 21: 91-96 (1992)
  25. Kim MS, Lee DC, Hong, JE, Chang KS, Cho HY, Kwon YK, Kim HY. Antimicrobial effects of ethanol extracts from Korean and Indonesian plants. Korean J. Food Sci. Technol. 32: 949-958 (2000)