Induction of Apoptosis by Immature Prunus salicina Lindl. cv. Soldam

피자두(Prunus salicina Lindl. cv. Soldam) 미숙과의 apoptosis 유도 효과

  • Yu, Mi-Hee (Department of Food Science and Technology, Keimyung University) ;
  • Im, Hyo-Gwon (Department of Food Science and Technology, Keimyung University) ;
  • HwangBo, Mi-Hyang (Department of Food Science and Technology, Keimyung University) ;
  • Lee, Ji-Won (Department of Food Science and Technology, Keimyung University) ;
  • Lee, In-Seon (The Center for Traditional Microorganism Resources, Keimyung University)
  • 유미희 (계명대학교 식품가공학 전공) ;
  • 임효권 (계명대학교 식품가공학 전공) ;
  • 황보미향 (계명대학교 식품가공학 전공) ;
  • 이지원 (계명대학교 식품가공학 전공) ;
  • 이인선 (계명대학교 전통미생물자원개발 및 산업화연구(TMR) 센터)
  • Published : 2005.04.30


Apoptosis of Prunus salicina Lindl. cv. Soldam, which possesses hematopoiesis, osteoporosis prevention, and antimutagenic effects, at different growth stages was evaluated. Cytotoxic effect of acetone extracts of immature fruits against various tumor cell lines was higher than that of mature fruits, particularly in hormone-independent human breast cancer, MDA-MB-231 cell line. Immature fruit extract increased expression level of pro-apoptotic protein Bax and reduced that of anti-apoptotic protein Bcl-2, and stimulated caspase-3 activity in MDA-MB-231 cells. Results suggest immature fruit of P. salicina Lindl. cv. soldam to be natural source for development of functional food and medical agents to prevent human breast cancer.


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