Antioxidative and Protective Effects of Ulmus davidiana var. japonica Extracts on Glutamate-Induced Cytotoxicity in PC 12 Cells

느릅나무 추출물의 항산화 효과 및 L-glutamate 유래 PC12 세포독성 보호효과

  • Choi, Won-Hee (Department of Food Function Research Division, Korea Food Research Institute) ;
  • Oh, Young-Sang (Department of Food Function Research Division, Korea Food Research Institute) ;
  • Kim, Sung-Ran (Department of Food Function Research Division, Korea Food Research Institute) ;
  • Ahn, Ji-Yoon (Department of Food Function Research Division, Korea Food Research Institute) ;
  • Ha, Tae-Youl (Department of Food Function Research Division, Korea Food Research Institute)
  • Published : 2005.06.30


Antioxidative and protective effects of Ulmus davidiana var. japonica against oxidative damages induced by glutamate in PC 12 cells were investigated. Inhibitory activity against $FeSO_{4}-H_{2}O_{2}$-induced oxidative stress and DPPH radical-scavenging activity were detected in ethyl acetate and butanol fractions of ethanol extracts from stems and roots. Ethyl acetate and butanol fractions of ethanol extracts from roots significantly inhibited glutamate-induced cytotoxicity and reactive oxygen species in PC 12 cells. These results demonstrate ethyl acetate and butanol fractions of ethanol extracts of U. davidiana var. japonica have potent protective effect against glutamate-induced oxidative stress.


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