Development of Analytical Method for Propylene Glycol in Foods

식품 중 프로필렌글리콜의 분석법 개발

  • 김희연 (경인지방식품의약품안전청 시험분석팀) ;
  • 홍기형 (식품의약품안전청 식품첨가물팀) ;
  • 최장덕 (식품의약품안전청 연구기획조정팀) ;
  • 박성관 (식품의약품안전청 식품첨가물팀) ;
  • 정시섭 ((주)랩프런티어) ;
  • 최우정 (식품의약품안전청 식품오염물질팀) ;
  • 이신호 (대구가톨릭대학교 식품.외식산업학부) ;
  • 문동철 (충북대학교 약학대학)
  • Published : 2005.12.31


Standardized method based on extraction, filtration, and gas chromatography (GC) was developed far propylene glycol analysis to set hygienic norm of safety measure for foods under governmental control. Various columns were tested fur propylene glycol analysis by GC with flame ionization detector. Known amount of propylene glycol was spiked into wheat flour dough and analyzed by developed method. Results showed 101.60% recovery rate for propylene glycol with HP-5 column. Reproducibility test of standards recorded 0.30 for standard variation and 0,42% for relative variation. Using analytical method established, contents of propylene glycol in more than hundred different foods were monitored. Propylene glycol was detected in most foods, indicating propylene glycol is not only commonly added during food preparation, but also is contained naturally in food.


propylene glycol;foods


  1. Veiga-Santos P, Oliveira LM, Cereda MP, Alves AJ, Scamparini ARP. Mechanical properties, hydrophilicity and water activity of starch-gum films: effect of additives and deacetylated xanthan gum. Food Hydrocolloids 19: 341-349 (2005)
  2. Godin CS, Pollard DL. Gas chromatography determination of propylene glycol dinitrate in rodent skin. J. Anal. Toxicol. 16: 356-358 (1992)
  3. Tomkins BA, Manning DL, Griest WH, Jones AR. Selective detector of 1,2-propylene glycol dinitrate, 1-propylene glycol mononitrate, and 2-propylene glycol mononitrate using gas chromatography/thermal energy analyzer or liquid chromatography/electrochemical detection. Anal. Chim. Acta 169: 69-78 (1985)
  4. Nardillo RCCM, Arancibia EL, Delfino MR. Solution and adsorption thermodynamics in propylene glycol by gas chromatography: A comparative study with other polyhydroxylated solvents. J. Chromatogr. A. 259: 413-422 (1983)
  5. Staples CA, Davis JW. An examination of the physical properties, fate, ecotoxicity and potential environmental risks for a series of propylene glycol ethers. Chemosphere 49: 61-73 (2002)
  6. Center for the Evaluation of Risks to Human Reproduction. NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of propylene glycol. Reprod. Toxicol. 18: 533-579 (2004)
  7. Mohamed SB, Stainsby G. Ability of various proteins to form thermostable gels with propylene glycol alginate. Food Chem. 13: 241-255 (1984)
  8. Sanchez VE, Bartholomai GB, Pilosof AMR. Rheological properties of food gums as related to their water binding capacity and to soy protein interaction. Lebensm.-Wiss.-u.-Technol. 28: 380-385 (1995)
  9. Houze P. Simultaneous determination of ethylene glycol, propylene glycol, 1,3-butylene glycol and 2,3-butylene glycol in human serum and urine by wide-bore column gas chromatography. J. Chromatogr.: Biomed. Appl. 619: 251-257 (1993)
  10. Ferrala NF, Ghanayem BI, Nomeir A. Determination of 1-methoxy-2- propanol and its metabolite 1,2-propanediol in rat and mouse plasma by gas chromatography. J. Chromatogr. B. 660: 291-296 (1994)
  11. KFDA. Korean Food Additives Code. Korea Food and Drug Administration, Seoul, Korea (2004)