Physiological Activities of Peel of Jeju-indigenous Citrus sunki Hort. Tanaka

제주자생 진귤(Citrus sunki Hort. Tanaka) 과피의 생리활성

  • Kang, Shin-Hae (Technology Innovation Center for Life Science, Cheju National University) ;
  • Lee, Young-Jae (Department of Verterinary Medicine, Cheju National University) ;
  • Lee, Chang-Hong (Center for Effective Microorganisms) ;
  • Kim, Se-Jae (Technology Innovation Center for Life Science, Cheju National University) ;
  • Lee, Dae-Ho (Department of Medicine, Cheju National University) ;
  • Lee, Young-Ki (Department of Medicine, Cheju National University) ;
  • Park, Deok-Bae (Department of Medicine, Cheju National University)
  • Published : 2005.12.31


Effects of Citrus sunki peel and its fermented product extracts on physiological and functional activities of cellular systems were investigated. Ethanol extract of Citrus sunki peel showed potent ROS-scavenging activity using 2',7'-Dichlorofluorescin diacetate as a fluorescent ROS probe in HepG2 cells. Fermented product of C. sunki peel extract markedly suppressed nitric oxide production in lipopolysaccharide (LPS)-activated RAW264.7 murine macrophage cells. Treatment with fermented product of C. sunki peel extract decreased intracellular protein levels of inducible nitric oxide synthase and cyclooxygenase II stimulated by LPS. High doses of fermented product lend to apoptotic cell death in CHO-IR cells.


Citrus sunki;fermentation;ROS;inflammation;apoptosis


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