Prevention of Photoaging and Wrinkle Formation in Hairless Mice Dorsal Skin by APB-03

Hairless mice에서의 대두 홍삼 혼합 분말(APB-03)의 경구 반복 투여 시 피부 주름 생성 예방 효과

  • Lee, Ji-Hae (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center) ;
  • Lee, Byoung-Seok (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center) ;
  • Yang, Mi-Suk (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center) ;
  • Byun, Bum-Sun (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center) ;
  • Kim, Wan-Gi (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center) ;
  • Kim, Bae-Hwan (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center) ;
  • Lee, Sang-Jun (Pharmaceutical & Health Research Institute, AmorePacific Corporation/R&D Center)
  • 이지해 ((주)태평양기술연구원 의약건강연구소) ;
  • 이병석 ((주)태평양기술연구원 의약건강연구소) ;
  • 양미숙 ((주)태평양기술연구원 의약건강연구소) ;
  • 변범선 ((주)태평양기술연구원 의약건강연구소) ;
  • 김완기 ((주)태평양기술연구원 의약건강연구소) ;
  • 김배환 ((주)태평양기술연구원 의약건강연구소) ;
  • 이상준 ((주)태평양기술연구원 의약건강연구소)
  • Published : 2005.12.31

Abstract

Ultraviolet (UV) induces photo aging, erythema, sunburn, photo-toxicity, photo-allergy, and skin tumor, To investigate photo-protective effects of AmorePacific Beauty-03 (APB-03; mixture of red ginseng extract powder and soybean extract powder) on UV-induced damaged skins, 40 SKH hairless female mice were orally administered APB-03 or saline five times a week and irradiated with UV three times per week far up to 12 weeks. Visible skin changes and skin damage in dermis and epidermis by replica image analysis and histological analysis. In APB-03-treated group, better skin, negative replica appearance and less wrinkle formation were observed compared to the UV control group. These results demonstrate oral administration of APB-03 have photo-protective effects on UV-damaged hairless mouse skin.

Keywords

soy and red ginseng extract mixture (APB-03);photo aging;wrinkle;hairless mouse;UV

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