Inhibition Effects of Natural Products on Osteoclast Differentiation

천연물 추출물의 파골세포 분화억제 효과 검색

  • Lee, Hyo-Jung (Department of Food Science & Technology, Keimyung University) ;
  • Yu, Mi-Hee (Department of Food Science & Technology, Keimyung University) ;
  • Lee, Syng-Ook (Department of Food Science & Technology, Keimyung University) ;
  • Kim, Hyun-Jeong (The Center for Traditional Microorganism Resources center, Keimyung University) ;
  • Lee, In-Seon (The Center for Traditional Microorganism Resources center, Keimyung University)
  • 이효정 (계명대학교 식품가공학과) ;
  • 유미희 (계명대학교 식품가공학과) ;
  • 이승욱 (계명대학교 식품가공학과) ;
  • 김현정 (계명대학교 전통미생물자원개발 및 산업화연구(TMR)센터) ;
  • 이인선 (계명대학교 전통미생물자원개발 및 산업화연구(TMR)센터)
  • Published : 2005.12.31


In bone remodeling imbalances that are caused by increased bone resorption over bone formation lead to adult skeletal diseases. Thus, we have screened various natural products for their ability to regulate the differentiation of osteoclasts to propose candidates for the prevention or treatment of osteoporosis. Scutellaria baicalensis Georgi and Zizyphus Jujuba Miller var. extracts of 140 natural products inhibited the differentiation of RAW264.7 cells into osteoclast, as showed by the reduced number of tartrate resistant acid phosphatase(TRAP)-positive multinucleated cells and decreased TRAP activity.


RAW264.7 cells;osteoclast;differentiation;natural products


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