Hypolipidemic Effects of Glycoprotein Isolated from Ficus Carica Linnoeus in Mice

무화과 당단백질의 혈중지질 저하 효과

  • Lim, Kye-Taek (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University) ;
  • Lee, Sei-Jung (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University) ;
  • Ko, Jeong-Hyeon (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University) ;
  • Oh, Phil-Sun (Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University)
  • 임계택 (전남대학교 생명공학 연구소) ;
  • 이세중 (전남대학교 생명공학 연구소) ;
  • 고정현 (전남대학교 생명공학 연구소) ;
  • 오필선 (전남대학교 생명공학 연구소)
  • Published : 2005.08.31

Abstract

Glycoprotein (60 kDa) isolated from Ficus Carica Linnoeus (FCL glycoprotein) was examined by evaluating its hypolipidemic effects on plasma cholesterol levels and hepatic detoxicant enzyme activities in ICR mice. FCL glycoprotein $(100{\mu}g/mL)$ had strong scavenging activities (38%) against lipid peroxyl radicals. When mice were treated with Triton WR-1339 (400 mg/kg), levels of total cholesterol (TC) and low-density lipoprotein (LDL)-cholesterol in plasma significantly increased by 53.9 and 47.5 mg/dL, respectively, compared to the control, whereas, when pretreated with FCL glycoprotein $(100{\mu}g/mL)$, decreased remarkably by 55.4, and 47,0 mg/dL, compared to Triton WR-1339 treatment alone. Interestingly, high-density lipoprotein (HDL)-cholesterol level did not change. Body and liver weights did not change significantly after Triton WR-1339 treatment in presence of FCL glycoprotein. FCL glycoprotein $(100{\mu}g/mL)$ stimulated activities of antioxidative detoxicant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), whereas GPx activity significantly increased compared to the control. These results suggest FCL glycoprotein has abilities to scavenge lipid peroxyl radicals, lower plasma lipid levels, and stimulate detoxicant enzyme activity in mouse liver.

Keywords

Ficus Carica Linnoeus (FCL);glycoprotein;plasma cholesterol;detoxicant enzymes

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