Effects of Fermented Milk Intake on Hepatic Antioxidative Systems in Alcohol treated Rats

알코올 투여한 쥐에서 발효유의 섭취가 간조직 내 항산화 체계에 미치는 영향

  • Ahn, Young-Tae (Research and Development Center, Korea Yakult Co., LTD.) ;
  • Bae, Jin-Seong (Research and Development Center, Korea Yakult Co., LTD.) ;
  • Kim, Yong-Hee (Research and Development Center, Korea Yakult Co., LTD.) ;
  • Lim, Kwang-Sei (Research and Development Center, Korea Yakult Co., LTD.) ;
  • Huh, Chul-Sung (Research and Development Center, Korea Yakult Co., LTD.)
  • 안영태 ((주)한국야쿠르트 중앙연구소) ;
  • 배진성 ((주)한국야쿠르트 중앙연구소) ;
  • 김용희 ((주)한국야쿠르트 중앙연구소) ;
  • 임광세 ((주)한국야쿠르트 중앙연구소) ;
  • 허철성 ((주)한국야쿠르트 중앙연구소)
  • Published : 2005.08.31


Effects of fermented milk, $Kupffer's^{\circledR}$, intake on hepatic antioxidative systems were investigated in rats fed ethanol (3 g/kg B.W.) for 2 weeks. Serum AST and ALT were $88.7{\pm}6.5\;and\;41.2{\pm}4.1IU/L$ in control group, $114.6{\pm}7.1\;and\;64.7{\pm}3.8IU/L$ in alcohol group, and $94.0{\pm}5.5\;and\;44.7{\pm}5.3IU/L$ in fermented milk (FM) group, respectively. Fermented milk intake decreased hepatic glutathione peroxidase and superoxide dismutase activities of FM group to level of control group (p<0.05). Glutathione S-transferase activity of fermented milk group increased by 122% compared to control group. These results suggest antioxidative activities of lactic acid bacteria and ingredients in $Kupffer's^{\circledR}$ improve antioxidative system in alcohol-treated rats.


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