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신장의 근위세뇨관에서 Renal Dipeptidase(RDPase)의 유도에 관한 키토산의 효과

Effects of Chitosan on the Induction of Renal Dipeptidase (RDPase) from the Proximal Tubules

  • 김영호 (조선대학교 자연과학대학 생물학과, 전남대학교 약학대학 약품개발연구소) ;
  • 윤현중 (전남대학교 약학대학 약품개발연구소) ;
  • 박행순 (전남대학교 약학대학 약품개발연구소) ;
  • 이명렬 (조선대학교 자연과학대학 식품영양학과) ;
  • 김종세 (조선대학교 자연과학대학 생물학과)
  • Kim, Young-Ho (Dept. of Natural Science, Biology, Chosun University, College of Pharmacy, Research Institute of Drug Development, Chonnam University) ;
  • Yoon, Hyun-Joong (College of Pharmacy, Research Institute of Drug Development, Chonnam University) ;
  • Park, Haeng-Soon (College of Pharmacy, Research Institute of Drug Development, Chonnam University) ;
  • Lee, Myung-Yul (Dept. of Food and Nutrition, Chosun University) ;
  • Kim, Jong-Se (Dept. of Natural Science, Biology, Chosun University)
  • 발행 : 2005.08.01

초록

기능성 식품소재로서 이미 많이 알려진 키토산이 신장과 관련하여 식품이나 의료용 소재로서 활용이 가능한 지를 알아보기 위하여 신장 기능과 민감하게 관련이 있는 효소인 RDPase, Udpase의 활성을 체내$\cdot$체외 실험을 통하여 관찰하였다. 체외 실험에서 글리세롤에 의해 유도된 RDPase의 유리$\cdot$활성 감소를 다시 회복시키는 것을 관찰하였다. 체내실험에서 글리세롤 투여에 의하여 손상된 신장의 근위세뇨관에서 급격히 증가한 RDPase의 활성을 키토산이 확실하게 감소시키는 것을 관찰할 수 있었다. 키토산을 공급한 쥐의 소변에서의 Udpase의 활성이 증가하는 것을 관찰하였다.

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