Inter-lab validation for the derivatization method by TFE/TFAA of acidic herbicides

산성 제초제류의 TFE/TFAA 유도체화 방법에 대한 실험실간 정도관리

  • Pyo, Hee-Soo (Bioanalysis & Biotransformation Research center, Korea Institute Science & Technology) ;
  • Park, Song-Ja (Bioanalysis & Biotransformation Research center, Korea Institute Science & Technology) ;
  • Lee, Kang-Jin (Water Analysis & Research Center, Woongjin coway CO. LTD) ;
  • Hong, Jong-Ki (Dept. of Pharmaceutical Science, Kyung Hee Univ.) ;
  • Shin, Ho-Sang (Dept. of Environmental Education, Kong Ju National Univ.)
  • 표희수 (한국과학기술연구원, 생체대사연구센터) ;
  • 박송자 (한국과학기술연구원, 생체대사연구센터) ;
  • 이강진 (웅진코웨이(주) 수질분석센터) ;
  • 홍종기 (경희대학교 약학과) ;
  • 신호상 (공주대학교 환경과학과)
  • Published : 2005.06.30

Abstract

A sensitive derivatization method by using the TFE/TFAA as derivative reagent is proposed for the determination of acidic herbicides in water, by using this method, method detection limits are improved by 10 times and sample volumes are decreased by 5 times compared with other methods such as U.S. EPA and SPEED 98. And also, in order to suggest higher creditable standard operating procedure (SOP), intra- and inter-lab validation test carried out by four laboratories include our lab. The results of intra and inter-lab validations in same experimental conditions show good linearity in given range of concentrations as a $0.1{\sim}10.0$ ng/ml, and range of accuracies and precisions show $-20.5{\sim}12.2$ bias%, $0.55{\sim}24.48%$ (for intra-lab validation) and $-6.66{\sim}0.80 bias%$, $1.92{\sim}13.86%$ (for inter-lab validation), respectively.

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