Anti-Obese Effects of Mixture Contained Pine needle, Black Tea and Green Tea Extracts

솔잎, 홍차 및 녹차 추출물 함유 조성물의 항비만 효과

  • Published : 2005.12.31

Abstract

The aims of this study were to evaluate the anti-obese effects of pine needle, black tea and green tea in rats and overweight people. Supplementation of 1, 2, 4 and 8% amount to the control diet of pine needle extract and mixture groups significantly decreased body weight gain and visceral fat mass compared with that of control diet group. Supplementation of 1, 2 and 4% amount to the control diet of black and green tea extracts groups significantly decreased body weight gain and visceral fat mass compared with that of control diet group. Anti-obese effect in body weight gain and visceral fat mass of mixture group was higher than in other groups. In human study, extracts mixture supplementation to overweight subjects significantly decreased both body weight and body fat compared with placebo control group. In vitro study, black and green tea extracts significantly inhibited both the pancreatic lipase and ${\alpha}-amylase$ activities dose dependently. In conclusion, the anti-obese effects of pine needle, black, and green teas in rats were found. In overweight human subjects, extracts mixture decreased body weight and body fat compared with placebo control group. Anti-obese effect in black and green tea groups might be from an decrease in carbohydrate and fat digestions via inhibition of pancreatic ${\alpha}-amylase$ and lipase activities in part.

Keywords

pine needle;black tea;green tea;visceral fat;pancreatic ${\alpha}$ amylase;lipase;obesity

References

  1. Chua, S. and Leibel, R. L. (1997) Obesity genes: molecular and metabolic mechanisms. Diabetes Rev. 5, 2-7
  2. Lee, C. H., Choi, B. K., Lee, W. C., Park, C.I., Yuziro F. and Kimura, S. (1992) Effect of dietary protein levels, caffeine and green tea on body fat deposition in Wistar Rats. J. Korean Soc. Food Nutr. 21, 595-600
  3. Chantre, P. and Lairon, D. (2002) Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 9, 3-8 https://doi.org/10.1078/0944-7113-00078
  4. Bates, S. H., Jones, R. B. and Bailey, C. J. (2000) Insuln-like effect of pinitol. Br. J. Pharmacol. 130, 1944-1948 https://doi.org/10.1038/sj.bjp.0703523
  5. Jang, E. C. (2003) Effects of black tea on body weight gain and visceral tat mass in rats. Korean J. Physical Edu. 41, 507-514
  6. Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus C., Jenkins, A. B. and Storlien, L. H. (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46, 983-988 https://doi.org/10.2337/diabetes.46.6.983
  7. Davis, A., Christiansen, M., Horowitz, J. E, Klein, S., Hellerstein, M. K. and Ostlund, R. E. Jr.(2000) Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care 23, 1000-1005 https://doi.org/10.2337/diacare.23.7.1000
  8. Storlien, L. H., Baur, L. A., Kriketos, A. D., Pan, D. A., Cooney, G. J., Jenkins, A. B., Calvert, G.D. and Campbell L.Y.(1996) Dietary fats and insulin action. Diabetologia 39, 621-631 https://doi.org/10.1007/BF00418533
  9. Balentine, D. A., Ho, C. T., Lee, C. Y. and Huang, M. T. (1991) Phenolic compounds in food and their effect on health analysis, occurrence and chemistry. American Chemical Society, Washington, DC, pp. 102-116
  10. Dullo, A. G., Seydoux, J., Girardier, L., Chantre, P. and Vandermander, J. (2000) Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int. J. Obes. Relat. Metab. Disord 24, 252-258 https://doi.org/10.1038/sj.ijo.0801101
  11. Sayama, K., Lin, S., Zheng, G. and Oguni, I. (2000) Effects of green tea on growth, food utilization and lipid metabolism in mice. In Vivo 14, 481-484
  12. Yamamoto, M., Shimura, S., Itoh, Y., Ohsaka, T., Egawa, M. and Inoue, S. (2000) Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-tat diet. Int. J. Obes. Relat. Metab. Disord 24, 758-764 https://doi.org/10.1038/sj.ijo.0801222
  13. Kim, J. Y., Nolte, L. A., Hansen, P. A., Han, D. H., Kawanaka, K. and Holloszy, J. O. (1999) Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet. Am. J. Physiol. 276, 665-672
  14. Yang, M. H., Wang, C. H. and Chen, H. L., (2001) Green, oolong and black tea extracts modulate lipid metabolism in hyperlipidemia rats fed high-sucrose diet. J. Nutr. Biochem. 12, 14-20 https://doi.org/10.1016/S0955-2863(00)00140-6
  15. Kim, J. Y., Nolte, L. A., Hansen, P. A., Han, D. H., Ferguson, K. and Holloszy, J. O.(2000) High tat diet induced muscle insulin resistance: Relationship to visceral fat mass. Am. J. Physiol. 279, 2057-2063
  16. Kim, S. M. and Cho, Y. S. (1999) Effect of pine needle extract on Fe ion and active oxygen related lipid oxidation in oil emulsion. Korean J-Harvest Sci Technol. Agri. Products 6, 115-120
  17. Jeon J. R. and Park, G. S. (1999) Korean green tea by Ku Jeung Ku Po's 1. Analysis of general compositions and chemical compositions. Korean J. Soc. Food Sci. 15, 95-101
  18. Sin, M. K., and Jung, W. H. (2000) The effect on rats serum lipid of treadmill exercise and green tea extracts intake with high tat diet. J. Korean Soc. Food Nutr. 29, 683-690
  19. Gupta, S., Saha, A. and Girl, A. K. (2002) Comparative antimutagenic and anticlastogenic effects of green tea and black tea: A review. Mutation Research 512, 37-65 https://doi.org/10.1016/S1383-5742(02)00024-8
  20. Horton, T. J. and Geissler, C. A. (1996) Post-prandial thermogenesis with ephedrine, caffeine and aspirin in lean, predisposed obese and obese women. Int. J. Obes. Relat. Metab. Disord 20, 91-97
  21. Kelley, D. E. and Mandarino, L. J. (2000) Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49, 677-683 https://doi.org/10.2337/diabetes.49.5.677
  22. Kelley, D. E., Thaete, F. L., Troost, F., Huwe, T. and Goodpaster, B. H. (2000) Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 278, 941-948
  23. Raz, I., Eldor, R., Cemea, S. and Shafrir, E. (2005) Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab. Res. Rev. 21, 3-14 https://doi.org/10.1002/dmrr.493
  24. Bernfeldt, P. (1955) Amylase, $\alpha$ and $\beta$, Methods in Enzymology 1, 149-150 https://doi.org/10.1016/0076-6879(55)01021-5
  25. Kao, Y. H., Hiipakka, R. A. and Liao, S. (2000) Modulation of obesity by a green tea catechin. Am. J. Clin. Nutr. 72, 1232-1234, 2000
  26. Dullo, A. G., Duret, C., Rohrer, D., et al.(1999) Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clin. Nutr. 70, 1040-1045
  27. Kim, E. S. and Kim, M. K. (1999) Effect of dried leaf powders and ethanol extracts of Persimmon, green tea and pine needle on lipid metabolism and antioxidative capacity in rats. Korean J. Nutrition 32, 337-352
  28. Lee, E. (2003) Effects of powdered pine needle (pinus densiflora seib et Zucc.) on serum and liver lipid composition and antioxidative capacity in rats fed high oxidized fat. J. Korean Soc. Food Nutr. 32, 926-930
  29. Lee, Y. J., An, M. S. and Hong K. H. (1998) A sudy on the content of general compounds, amino acid, vitamins, catechins, alkaloids in green, Oolong and black tea. J. Fd. Hyg. Safety 13, 377-382