Journal of KIISE:Computing Practices and Letters (한국정보과학회논문지:컴퓨팅의 실제 및 레터)

Korean Institute of Information Scientists and Engineers (한국정보과학회)
권호 표지

PreSPI: Protein-Protein Interaction Prediction Service System

PreSPI: 단백질 상호작용 예측 서비스 시스템

  • 한동수 (한국정보통신대학교 공학부) ;
  • 김홍숙 (한국전자통신연구원 이동통신연구단) ;
  • 장우혁 (한국정보통신대학교 공학부) ;
  • 이성독 (한국정보통신대학교 공학부)
  • Published : 2005.12.01

Abstract

With the recognition of the importance of computational approach for protein-protein interaction prediction, many techniques have been developed to computationally predict protein-protein interactions. However, few techniques are actually implemented and announced in service form for general users to readily access and use the techniques. In this paper, we design and implement a protein interaction prediction service system based on the domain combination based protein-protein interaction prediction technique, which is known to show superior accuracy to other conventional computational protein-protein interaction prediction methods. In the prediction accuracy test of the method, high sensitivity($77\%$) and specificity($95\%$) are achieved for test protein pairs containing common domains with teaming sets of proteins in a Yeast. The stability of the method is also manifested through the testing over DIP CORE, HMS-PCI, and TAP data. Performance, openness and flexibility are the major design goals and they are achieved by adopting parallel execution techniques, web Services standards, and layered architecture respectively. In this paper, several representative user interfaces of the system are also introduced with comprehensive usage guides.

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