The Experimental Study of EjinTang-Gamybang (Erchentang-jiaweifang) on the Obesity in Rats - Focusing on Lipid-metabolism, Blood pressure, Cerebral Blood Flow -

이진탕가미방(二陳湯加味方)이 비만(肥滿)에 미치는 실험적(實驗的) 연구(硏究) - 지질대사, 혈압, 뇌혈류량을 중심으로 -

  • Kim, Ki-Hyeng (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University) ;
  • Choi, Jin-Bong (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University)
  • 김기형 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 최진봉 (동신대학교 한의과대학 한방재활의학과교실)
  • Received : 2005.03.29
  • Accepted : 2005.04.22
  • Published : 2005.04.30
  • 57 0


Abstract

Objectives : This experimental study was designed to investigate the effects of EjinTang-Gamybang(Erchentang-jiaweifang ; ETG) on the change of some values related to obesity and observe the complications coming from obesity in obese rat induced by high fat diet. Methods : Experimental group were as follows ; normal group were fed normal diet and administered DDW $1.0m{\ell}$ to rat during 7 weeks, control group were fed high fat diet and administered DDW $1.0m{\ell}$ during 7 weeks, sample A were fed high fat diet and administered ETG 500 mg/kg $1.0m{\ell}$ during 7 weeks, sample B were fed high fat diet and administered ETG 700 mg/kg $1.0m{\ell}$ during 7 weeks. Results & Conclusions : 1. Sample A and Sample B significantly decreased body weight, serum LDL-cholesterol level, serum free fatty acid level, serum total lipid level, serum phospholipid level and serum leptin level in comparison with control group. 2. Sample B significantly decreased serum total cholesterol level and serum triglyceride level in comparison with control group. 3. Sample B significantly increased serum HDL-cholesterol level in comparison with control group. According to above results, the author suggested that ETG was able to be used for the herbal medication of obesity. 4. ETG significantly increased rCBF, and increased CMF in a dose-dependent. 5. ETG significantly decreased MABP in a dose-dependent. 6. rCBF was significantly and stably increased by ETG(10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. This results were suggested that ETG significantly increased rCBF by dilating arterial diameter and activating serum leptin level. So that, the present author thought that ETG had an effects of obesity and complication coming from obesity(ischemic cerebral and cardiac disease).

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